DHX58 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of DHX58 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DHX58 at tissue level.

III. Associated gene sets

GO_0009617Biological processresponse to bacterium
GO_0009615Biological processresponse to virus
GO_0032481Biological processpositive regulation of type I interferon production
GO_0039536Biological processnegative regulation of RIG-I signaling pathway
GO_0039534Biological processnegative regulation of MDA-5 signaling pathway
GO_0032480Biological processnegative regulation of type I interferon production
GO_0045088Biological processregulation of innate immune response
GO_0045824Biological processnegative regulation of innate immune response
GO_1900246Biological processpositive regulation of RIG-I signaling pathway
GO_1900245Biological processpositive regulation of MDA-5 signaling pathway
GO_0002753Biological processcytoplasmic pattern recognition receptor signaling pathway
GO_0140374Biological processantiviral innate immune response
GO_0005737Cellular componentcytoplasm
GO_0003677Molecular functionDNA binding
GO_0003727Molecular functionsingle-stranded RNA binding
GO_0003724Molecular functionRNA helicase activity
GO_0008270Molecular functionzinc ion binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity
GO_0003725Molecular functiondouble-stranded RNA binding

IV. Literature review

[source]
Gene nameDHX58
Protein nameRNA helicase (EC 3.6.4.13)
ATP-dependent RNA helicase DHX58 (EC 3.6.4.13) (ATP-dependent helicase LGP2) (Protein D11Lgp2 homolog) (RIG-I-like receptor 3) (RLR-3) (RIG-I-like receptor LGP2) (RLR)
DExH-box helicase 58
SynonymshCG_15679
LGP2
D11LGP2E
DescriptionFUNCTION: Acts as a regulator of RIGI and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can have both negative and positive regulatory functions related to RIGI and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on RIG-I signaling may involve the following mechanisms: competition with RIGI for binding to the viral RNA, binding to RIGI and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by RIGI and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses and coronavirus SARS-CoV-2, and also to the bacterial pathogen Listeria monocytogenes . Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate. .

AccessionsENST00000413196.6
ENST00000430773.1
C9JG98
K7EPP0
ENST00000589979.1
K7EMZ5
ENST00000591220.5
Q96C10
A0AA51U9C6
C9JE76
ENST00000251642.8