DHX33 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006413Biological processtranslational initiation
GO_0032481Biological processpositive regulation of type I interferon production
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_1900227Biological processpositive regulation of NLRP3 inflammasome complex assembly
GO_0045943Biological processpositive regulation of transcription by RNA polymerase I
GO_0005730Cellular componentnucleolus
GO_0072559Cellular componentNLRP3 inflammasome complex
GO_0005622Cellular componentintracellular anatomical structure
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0004386Molecular functionhelicase activity
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0003724Molecular functionRNA helicase activity
GO_0003729Molecular functionmRNA binding
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding
GO_0043023Molecular functionribosomal large subunit binding
GO_0000182Molecular functionrDNA binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity
GO_0003725Molecular functiondouble-stranded RNA binding

IV. Literature review

[source]
Gene nameDHX33
Protein nameATP-dependent RNA helicase DHX33 (EC 3.6.4.13) (DEAH box protein 33)
DEAH-box helicase 33
RNA helicase (EC 3.6.4.13)
SynonymshCG_1985693
DDX33
DescriptionFUNCTION: Implicated in nucleolar organization, ribosome biogenesis, protein synthesis and cytoplasmic dsRNA sensing (By similarity) . Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA (rDNA) loci where it is involved in POLR1A recruitment . In the cytoplasm, promotes elongation-competent 80S ribosome assembly at the late stage of mRNA translation initiation . Senses cytosolic dsRNA mediating NLRP3 inflammasome formation in macrophages and type I interferon production in myeloid dendritic cells . Required for NLRP3 activation induced by viral dsRNA and bacterial RNA . In dendritic cells, required for induction of type I interferon production induced by cytoplasmic dsRNA via the activation of MAPK and NF-kappa-B signaling pathways (By similarity). .

AccessionsQ05BE5
I3L1L6
I3L0M5
ENST00000572490.1
ENST00000574023.1
ENST00000225296.8 [Q9H6R0-1]
ENST00000433302.7
Q9H6R0