I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 3 studies | 23% ± 4% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| epithelial cell | 3 studies | 23% ± 4% |
Insufficient scRNA-seq data for expression of DHX16 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 3081.40 | 1445 / 1445 | 100% | 40.15 | 183 / 183 |
| lung | 100% | 3483.19 | 578 / 578 | 100% | 43.62 | 1155 / 1155 |
| prostate | 100% | 4062.80 | 245 / 245 | 100% | 34.67 | 502 / 502 |
| skin | 100% | 3685.44 | 1809 / 1809 | 100% | 64.95 | 472 / 472 |
| breast | 100% | 3699.54 | 459 / 459 | 100% | 43.56 | 1117 / 1118 |
| thymus | 100% | 5358.82 | 653 / 653 | 100% | 39.38 | 604 / 605 |
| uterus | 100% | 3860.12 | 170 / 170 | 100% | 49.78 | 458 / 459 |
| pancreas | 100% | 2410.54 | 327 / 328 | 100% | 38.69 | 178 / 178 |
| stomach | 100% | 2897.37 | 359 / 359 | 100% | 36.27 | 285 / 286 |
| intestine | 100% | 3818.87 | 966 / 966 | 100% | 39.92 | 525 / 527 |
| bladder | 100% | 3393.05 | 21 / 21 | 100% | 44.40 | 502 / 504 |
| ovary | 100% | 3358.60 | 180 / 180 | 100% | 35.05 | 428 / 430 |
| liver | 100% | 2259.23 | 226 / 226 | 100% | 32.25 | 404 / 406 |
| kidney | 100% | 3783.25 | 89 / 89 | 98% | 28.47 | 885 / 901 |
| adrenal gland | 100% | 3396.32 | 258 / 258 | 97% | 31.32 | 224 / 230 |
| brain | 96% | 1565.70 | 2532 / 2642 | 100% | 33.90 | 705 / 705 |
| adipose | 100% | 3334.06 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 50.30 | 29 / 29 |
| muscle | 100% | 3673.70 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 5046.15 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 54.88 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 30.63 | 1 / 1 |
| blood vessel | 100% | 2930.14 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| heart | 99% | 2014.69 | 853 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 99% | 46.99 | 79 / 80 |
| peripheral blood | 98% | 2995.08 | 915 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0000398 | Biological process | mRNA splicing, via spliceosome |
| GO_0008380 | Biological process | RNA splicing |
| GO_0140374 | Biological process | antiviral innate immune response |
| GO_0071005 | Cellular component | U2-type precatalytic spliceosome |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005622 | Cellular component | intracellular anatomical structure |
| GO_0005681 | Cellular component | spliceosomal complex |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0004386 | Molecular function | helicase activity |
| GO_0043130 | Molecular function | ubiquitin binding |
| GO_0038187 | Molecular function | pattern recognition receptor activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0060090 | Molecular function | molecular adaptor activity |
| GO_0003724 | Molecular function | RNA helicase activity |
| GO_0016887 | Molecular function | ATP hydrolysis activity |
| GO_0005524 | Molecular function | ATP binding |
| GO_0003723 | Molecular function | RNA binding |
| Gene name | DHX16 |
| Protein name | DEAH-box helicase 16 (Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16) Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 RNA helicase (EC 3.6.4.13) DHX16 protein Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (EC 3.6.4.13) (ATP-dependent RNA helicase #3) (DEAH-box protein 16) |
| Synonyms | DDX16 DBP2 KIAA0577 hCG_26008 PRP2 |
| Description | FUNCTION: Required for pre-mRNA splicing as component of the spliceosome . Contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Plays also a role in innate antiviral response by acting as a pattern recognition receptor sensing splicing signals in viral RNA . Mechanistically, TRIM6 promotes the interaction between unanchored 'Lys-48'-polyubiquitin chains and DHX16, leading to DHX16 interaction with RIGI and ssRNA to amplify RIGI-dependent innate antiviral immune responses . . |
| Accessions | ENST00000453879.2 ENST00000449861.6 ENST00000450902.6 ENST00000447945.1 A0A140T8Y5 ENST00000451456.6 ENST00000445379.6 ENST00000383577.8 ENST00000451748.6 ENST00000436662.1 ENST00000417308.6 A0A140T947 ENST00000448766.1 ENST00000421095.6 ENST00000427297.1 ENST00000424672.6 ENST00000458094.6 ENST00000414052.6 ENST00000456005.5 ENST00000450691.1 A0A1U9X7L7 ENST00000383576.7 ENST00000449252.1 ENST00000446074.1 O60231 ENST00000415603.1 Q6PKC8 A0A140T9T4 A2AB15 ENST00000376442.8 Q5SQH4 Q5SQH5 ENST00000376437.9 |
