Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| adipocyte | 9 studies | 32% ± 7% | |
| epithelial cell | 5 studies | 22% ± 3% | |
| retinal cone cell | 5 studies | 39% ± 7% | |
| goblet cell | 4 studies | 30% ± 14% | |
| retinal rod cell | 3 studies | 20% ± 2% | |
| GABAergic neuron | 3 studies | 38% ± 11% | |
| glutamatergic neuron | 3 studies | 48% ± 15% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 2290.43 | 1445 / 1445 | 100% | 20.08 | 183 / 183 |
| prostate | 100% | 1913.77 | 245 / 245 | 100% | 22.70 | 502 / 502 |
| skin | 100% | 3048.33 | 1809 / 1809 | 100% | 29.61 | 472 / 472 |
| uterus | 100% | 1830.39 | 170 / 170 | 100% | 23.02 | 459 / 459 |
| breast | 100% | 3329.02 | 459 / 459 | 100% | 26.55 | 1117 / 1118 |
| kidney | 100% | 2165.30 | 89 / 89 | 100% | 23.42 | 900 / 901 |
| thymus | 100% | 2060.01 | 653 / 653 | 100% | 23.84 | 604 / 605 |
| intestine | 100% | 2696.27 | 966 / 966 | 100% | 21.05 | 526 / 527 |
| bladder | 100% | 2042.62 | 21 / 21 | 100% | 22.43 | 503 / 504 |
| ovary | 100% | 1483.89 | 180 / 180 | 100% | 18.38 | 429 / 430 |
| stomach | 100% | 1856.06 | 358 / 359 | 100% | 19.63 | 286 / 286 |
| pancreas | 99% | 1284.12 | 326 / 328 | 100% | 20.28 | 178 / 178 |
| lung | 99% | 1810.16 | 572 / 578 | 100% | 22.85 | 1155 / 1155 |
| liver | 100% | 1381.52 | 225 / 226 | 99% | 13.71 | 403 / 406 |
| brain | 99% | 3203.11 | 2610 / 2642 | 100% | 22.50 | 705 / 705 |
| adrenal gland | 100% | 2335.84 | 258 / 258 | 99% | 20.56 | 227 / 230 |
| adipose | 100% | 3978.48 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 17.66 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 19.53 | 29 / 29 |
| spleen | 100% | 1829.07 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 23.11 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 36.72 | 1 / 1 |
| blood vessel | 100% | 2147.72 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 96% | 961.11 | 773 / 803 | 0% | 0 | 0 / 0 |
| heart | 96% | 1321.92 | 824 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 83% | 1071.12 | 774 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006489 | Biological process | dolichyl diphosphate biosynthetic process |
| GO_0016094 | Biological process | polyprenol biosynthetic process |
| GO_1904423 | Cellular component | dehydrodolichyl diphosphate synthase complex |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0045547 | Molecular function | dehydrodolichyl diphosphate synthase activity |
| GO_0002094 | Molecular function | polyprenyltransferase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0046872 | Molecular function | metal ion binding |
| Gene name | DHDDS |
| Protein name | Alkyl transferase (EC 2.5.1.-) Dehydrodolichyl diphosphate synthase complex subunit DHDDS (EC 2.5.1.87) (Cis-isoprenyltransferase) (CIT) (Cis-IPTase) (Cis-prenyltransferase subunit hCIT) (Epididymis tissue protein Li 189m) ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyldiphosphate specific] (EC 2.5.1.87) |
| Synonyms | HDS |
| Description | FUNCTION: With NUS1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER) . Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length . Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol . . |
| Accessions | E9PL99 A0A8V8TRI4 ENST00000533087.5 E9PKJ5 ENST00000531312.5 ENST00000525682.6 [Q86SQ9-4] ENST00000525546.5 ENST00000703200.1 ENST00000525165.5 Q5T0A3 ENST00000374185.7 ENST00000526219.5 [Q86SQ9-3] ENST00000703198.1 Q5T0A2 ENST00000360009.6 [Q86SQ9-2] E9PI09 ENST00000430232.5 Q5T0A6 A0A8V8TQS0 ENST00000525326.5 E9PR24 ENST00000703203.1 A0A8V8TQU2 ENST00000703262.1 A0A8V8TQ96 ENST00000528557.6 [Q86SQ9-1] E9PI64 ENST00000434391.6 ENST00000416052.1 A0A8V8TR89 E9PRS7 ENST00000436153.6 A0A8V8TQQ9 ENST00000431933.5 Q5T0A0 ENST00000236342.12 [Q86SQ9-1] ENST00000427245.6 E9PSH7 H0Y4T1 Q5T0A1 ENST00000703202.1 Q86SQ9 ENST00000703201.1 A0A8V8TQ81 ENST00000530781.5 ENST00000703199.1 ENST00000703263.1 |
