Name | Number of supported studies | Average coverage | |
---|---|---|---|
plasma cell | 4 studies | 26% ± 13% | |
classical monocyte | 4 studies | 23% ± 7% | |
epithelial cell | 4 studies | 32% ± 11% | |
conventional dendritic cell | 3 studies | 23% ± 5% | |
non-classical monocyte | 3 studies | 30% ± 6% | |
endothelial cell | 3 studies | 18% ± 2% | |
basal cell | 3 studies | 24% ± 5% | |
GABAergic neuron | 3 studies | 30% ± 7% | |
glutamatergic neuron | 3 studies | 33% ± 9% | |
dendritic cell | 3 studies | 28% ± 9% | |
CD4-positive, alpha-beta T cell | 3 studies | 26% ± 3% | |
CD8-positive, alpha-beta T cell | 3 studies | 21% ± 3% | |
regulatory T cell | 3 studies | 24% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
bladder | 100% | 2548.24 | 21 / 21 | 100% | 35.31 | 504 / 504 |
brain | 100% | 4417.69 | 2642 / 2642 | 100% | 62.46 | 705 / 705 |
esophagus | 100% | 3379.77 | 1445 / 1445 | 100% | 38.08 | 183 / 183 |
intestine | 100% | 2553.75 | 966 / 966 | 100% | 40.05 | 527 / 527 |
kidney | 100% | 3059.12 | 89 / 89 | 100% | 31.91 | 901 / 901 |
liver | 100% | 4938.23 | 226 / 226 | 100% | 45.07 | 406 / 406 |
prostate | 100% | 2720.43 | 245 / 245 | 100% | 38.78 | 502 / 502 |
skin | 100% | 3262.30 | 1809 / 1809 | 100% | 51.75 | 472 / 472 |
stomach | 100% | 2553.94 | 359 / 359 | 100% | 37.53 | 286 / 286 |
lung | 100% | 3086.65 | 577 / 578 | 100% | 44.92 | 1155 / 1155 |
uterus | 100% | 2266.01 | 170 / 170 | 100% | 31.42 | 458 / 459 |
ovary | 100% | 2429.74 | 180 / 180 | 100% | 24.30 | 429 / 430 |
breast | 100% | 2341.68 | 459 / 459 | 100% | 30.87 | 1114 / 1118 |
thymus | 100% | 2018.05 | 652 / 653 | 100% | 22.81 | 603 / 605 |
pancreas | 100% | 1427.37 | 327 / 328 | 99% | 27.76 | 176 / 178 |
adrenal gland | 100% | 3399.17 | 258 / 258 | 98% | 25.27 | 225 / 230 |
adipose | 100% | 2322.18 | 1204 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 44.02 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 41.40 | 29 / 29 |
spleen | 100% | 2671.01 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 32.38 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 26.83 | 1 / 1 |
blood vessel | 100% | 2157.27 | 1334 / 1335 | 0% | 0 | 0 / 0 |
muscle | 99% | 1833.55 | 794 / 803 | 0% | 0 | 0 / 0 |
heart | 99% | 4337.89 | 850 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 97% | 2595.20 | 899 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0032434 | Biological process | regulation of proteasomal ubiquitin-dependent protein catabolic process |
GO_0070646 | Biological process | protein modification by small protein removal |
GO_0098734 | Biological process | macromolecule depalmitoylation |
GO_0016926 | Biological process | protein desumoylation |
GO_0006611 | Biological process | protein export from nucleus |
GO_0006508 | Biological process | proteolysis |
GO_0032991 | Cellular component | protein-containing complex |
GO_0005829 | Cellular component | cytosol |
GO_0005634 | Cellular component | nucleus |
GO_0052816 | Molecular function | long-chain fatty acyl-CoA hydrolase activity |
GO_0008474 | Molecular function | palmitoyl-(protein) hydrolase activity |
GO_0016929 | Molecular function | deSUMOylase activity |
GO_0042802 | Molecular function | identical protein binding |
GO_0005515 | Molecular function | protein binding |
GO_0061676 | Molecular function | importin-alpha family protein binding |
Gene name | DESI1 |
Protein name | Desumoylating isopeptidase 1 (DeSI-1) (EC 3.4.-.-) (PPPDE peptidase domain-containing protein 2) (Palmitoyl protein thioesterase DESI1) (EC 3.1.2.22) (Polyubiquitinated substrate transporter) (POST) (S-depalmitoylase DESI1) |
Synonyms | PPPDE2 FAM152B |
Description | FUNCTION: Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins. Has isopeptidase but not SUMO-processing activity (By similarity). Desumoylates ZBTB46 (By similarity). Collaborates with UBQLN4 in the export of ubiquitinated proteins from the nucleus to the cytoplasm . Exhibits palmitoyl protein thioesterase (S-depalmitoylation) activity towards synthetic substrates 4-methylumbelliferyl-6-S-palmitoyl-beta-D-glucopyranoside and S-depalmitoylation probe 5 (DPP-5) . . |
Accessions | ENST00000263256.7 Q6ICB0 |