DESI1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032434Biological processregulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0070646Biological processprotein modification by small protein removal
GO_0098734Biological processmacromolecule depalmitoylation
GO_0016926Biological processprotein desumoylation
GO_0006611Biological processprotein export from nucleus
GO_0006508Biological processproteolysis
GO_0032991Cellular componentprotein-containing complex
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0052816Molecular functionlong-chain fatty acyl-CoA hydrolase activity
GO_0008474Molecular functionpalmitoyl-(protein) hydrolase activity
GO_0016929Molecular functiondeSUMOylase activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0061676Molecular functionimportin-alpha family protein binding

IV. Literature review

[source]
Gene nameDESI1
Protein nameDesumoylating isopeptidase 1 (DeSI-1) (EC 3.4.-.-) (PPPDE peptidase domain-containing protein 2) (Palmitoyl protein thioesterase DESI1) (EC 3.1.2.22) (Polyubiquitinated substrate transporter) (POST) (S-depalmitoylase DESI1)
SynonymsPPPDE2
FAM152B
DescriptionFUNCTION: Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins. Has isopeptidase but not SUMO-processing activity (By similarity). Desumoylates ZBTB46 (By similarity). Collaborates with UBQLN4 in the export of ubiquitinated proteins from the nucleus to the cytoplasm . Exhibits palmitoyl protein thioesterase (S-depalmitoylation) activity towards synthetic substrates 4-methylumbelliferyl-6-S-palmitoyl-beta-D-glucopyranoside and S-depalmitoylation probe 5 (DPP-5) . .

AccessionsENST00000263256.7
Q6ICB0