DDX56 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051607Biological processdefense response to virus
GO_0032480Biological processnegative regulation of type I interferon production
GO_0006364Biological processrRNA processing
GO_0010976Biological processpositive regulation of neuron projection development
GO_0044830Biological processmodulation by host of viral RNA genome replication
GO_0005730Cellular componentnucleolus
GO_0005829Cellular componentcytosol
GO_0016020Cellular componentmembrane
GO_0005634Cellular componentnucleus
GO_0140311Molecular functionprotein sequestering activity
GO_0035613Molecular functionRNA stem-loop binding
GO_0005515Molecular functionprotein binding
GO_0003724Molecular functionRNA helicase activity
GO_0016887Molecular functionATP hydrolysis activity
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameDDX56
Protein nameDEAD-box helicase 56
RNA helicase (EC 3.6.4.13)
Probable ATP-dependent RNA helicase DDX56 (EC 3.6.4.13) (ATP-dependent 61 kDa nucleolar RNA helicase) (DEAD box protein 21) (DEAD box protein 56)
SynonymshCG_18300
NOH61
DDX21
DescriptionFUNCTION: Nucleolar RNA helicase that plays a role in various biological processes including innate immunity, ribosome biogenesis or nucleolus organization . Plays an essential role in maintaining nucleolar integrity in planarian stem cells . Maintains embryonic stem cells proliferation by conventional regulation of ribosome assembly and interaction with OCT4 and POU5F1 complex (By similarity). Regulates antiviral innate immunity by inhibiting the virus-triggered signaling nuclear translocation of IRF3 . Mechanistically, acts by disrupting the interaction between IRF3 and importin IPO5 . May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity. .; FUNCTION: (Microbial infection) Helicase activity is important for packaging viral RNA into virions during West Nile virus infection. .; FUNCTION: (Microbial infection) Plays a positive role in foot-and-mouth disease virus replication by inhibiting the phosphorylation of IRF3 leading to inhibition of type I interferon. .; FUNCTION: (Microbial infection) Plays a positive role in EMCV replication by interrupting IRF3 phosphorylation and its nucleus translocation. .

AccessionsH7BZN7
H7C3E9
ENST00000415758.1
G3V0G3
ENST00000446987.5
ENST00000448192.1
ENST00000433257.5
Q9NY93
ENST00000421223.5
ENST00000431640.5 [Q9NY93-2]
F8WEI3
F8WDT8
ENST00000258772.10 [Q9NY93-1]