DCLRE1C report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0002250Biological processadaptive immune response
GO_0033151Biological processV(D)J recombination
GO_0006303Biological processdouble-strand break repair via nonhomologous end joining
GO_0036297Biological processinterstrand cross-link repair
GO_0010212Biological processresponse to ionizing radiation
GO_0030183Biological processB cell differentiation
GO_0000723Biological processtelomere maintenance
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0070419Cellular componentnonhomologous end joining complex
GO_0004519Molecular functionendonuclease activity
GO_0035312Molecular function5'-3' DNA exonuclease activity
GO_0000014Molecular functionsingle-stranded DNA endodeoxyribonuclease activity
GO_0008409Molecular function5'-3' exonuclease activity
GO_0005515Molecular functionprotein binding
GO_0003684Molecular functiondamaged DNA binding

IV. Literature review

[source]
Gene nameDCLRE1C
Protein nameProtein artemis (DNA cross-link repair 1C protein)
Protein artemis (EC 3.1.-.-) (DNA cross-link repair 1C protein) (Protein A-SCID) (SNM1 homolog C) (hSNM1C) (SNM1-like protein)
DNA cross-link repair 1C
SynonymsSNM1C
SCIDA
ASCID
ARTEMIS
DescriptionFUNCTION: Nuclease involved in DNA non-homologous end joining (NHEJ); required for double-strand break repair and V(D)J recombination . Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments . V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs) . These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends . These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively . This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC . The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint . Also required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ . .

AccessionsA0A8V8TKP5
A0A8V8TL07
A0A9S7JK93
ENST00000697084.1
A0A8V8TKH3
ENST00000697087.1
ENST00000456122.2
ENST00000697076.1
ENST00000697077.1
ENST00000492201.6
ENST00000378241.6
ENST00000697088.1
ENST00000489161.2
ENST00000697072.1
ENST00000697081.1
ENST00000378254.5
ENST00000396817.6
ENST00000697078.1
A0A8V8TKM6
ENST00000697047.1
ENST00000378246.6
ENST00000697080.1
ENST00000697082.1
ENST00000357717.6
ENST00000378255.5
ENST00000697071.1
ENST00000697075.1 [Q96SD1-1]
A0A8V8TM57
ENST00000378289.8 [Q96SD1-4]
A0A9S7JGJ5
ENST00000697073.1
ENST00000378258.5
Q96SD1
ENST00000697089.1
ENST00000697085.1
A0A8V8TLX1
ENST00000378278.7 [Q96SD1-1]
A0A8V8TKN9
A0A8V8TLW6
ENST00000378249.5
A0A8V8TKM3
ENST00000697074.1
ENST00000697070.1
ENST00000697083.1