DBR1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of DBR1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DBR1 at tissue level.

III. Associated gene sets

GO_0000398Biological processmRNA splicing, via spliceosome
GO_0000375Biological processRNA splicing, via transesterification reactions
GO_0000292Biological processRNA fragment catabolic process
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0008419Molecular functionRNA lariat debranching enzyme activity
GO_0046872Molecular functionmetal ion binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameDBR1
Protein nameDebranching RNA lariats 1
Lariat debranching enzyme (EC 3.1.4.-)
Synonyms
DescriptionFUNCTION: Cleaves the 2'-5' phosphodiester linkage at the branch point of excised lariat intron RNA and converts them into linear molecules that can be subsequently degraded, thereby facilitating ribonucleotide turnover . Linked to its role in pre-mRNA processing mechanism, may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis and have an antiviral cell-intrinsic defense function in the brainstem . .

AccessionsENST00000477557.3
A0A8V8TMF7
ENST00000698925.1
A0A8V8TP85
A0A8V8TMH0
ENST00000698922.1
ENST00000260803.9 [Q9UK59-1]
F8WAY1
A0A8V8TMX5
ENST00000698923.1
A0A8V8TNX0
Q9UK59
ENST00000698924.1
ENST00000698926.1