CYP1B1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
classical monocyte	22 studies	29% ± 13%	Explore
fibroblast	21 studies	39% ± 19%	Explore
vein endothelial cell	10 studies	27% ± 11%	Explore
connective tissue cell	8 studies	39% ± 13%	Explore
endothelial cell	7 studies	26% ± 12%	Explore
endothelial cell of artery	7 studies	23% ± 5%	Explore
smooth muscle cell	6 studies	30% ± 10%	Explore
adventitial cell	5 studies	27% ± 5%	Explore
endothelial cell of vascular tree	5 studies	25% ± 5%	Explore
myofibroblast cell	4 studies	21% ± 7%	Explore
epithelial cell	4 studies	30% ± 12%	Explore
macrophage	4 studies	36% ± 21%	Explore
monocyte	3 studies	20% ± 3%	Explore
kidney loop of Henle epithelial cell	3 studies	21% ± 2%	Explore
basal cell	3 studies	21% ± 2%	Explore
secretory cell	3 studies	37% ± 6%	Explore
endothelial cell of lymphatic vessel	3 studies	21% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
uterus	3 studies	25% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	4554.87	457 / 459	93%	59.25	1041 / 1118
prostate	97%	5910.99	238 / 245	95%	92.12	477 / 502
lung	93%	4257.66	536 / 578	84%	33.95	969 / 1155
kidney	90%	2986.71	80 / 89	68%	28.12	611 / 901
thymus	78%	2193.62	509 / 653	80%	75.88	482 / 605
uterus	99%	6276.36	168 / 170	37%	17.39	172 / 459
bladder	86%	1739.14	18 / 21	35%	12.79	177 / 504
skin	77%	3430.65	1388 / 1809	37%	7.49	176 / 472
stomach	69%	3350.77	248 / 359	33%	9.27	93 / 286
adrenal gland	88%	1862.65	227 / 258	13%	8.40	29 / 230
pancreas	18%	265.69	58 / 328	81%	34.00	145 / 178
spleen	98%	3443.81	237 / 241	0%	0	0 / 0
adipose	98%	4751.39	1182 / 1204	0%	0	0 / 0
ovary	44%	1182.73	80 / 180	54%	12.88	231 / 430
esophagus	64%	1608.34	920 / 1445	27%	7.49	50 / 183
heart	85%	3900.19	732 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	83%	22.82	24 / 29
blood vessel	76%	2384.20	1021 / 1335	0%	0	0 / 0
intestine	47%	799.99	451 / 966	18%	5.75	97 / 527
peripheral blood	64%	3639.98	592 / 929	0%	0	0 / 0
liver	26%	445.87	59 / 226	36%	14.42	148 / 406
tonsil	0%	0	0 / 0	53%	15.77	24 / 45
brain	22%	313.22	594 / 2642	27%	6.88	187 / 705
muscle	18%	264.09	142 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	4%	0.28	3 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0007584	Biological process	response to nutrient
GO_0044849	Biological process	estrous cycle
GO_0032355	Biological process	response to estradiol
GO_0001525	Biological process	angiogenesis
GO_0008285	Biological process	negative regulation of cell population proliferation
GO_2000377	Biological process	regulation of reactive oxygen species metabolic process
GO_0006805	Biological process	xenobiotic metabolic process
GO_0045766	Biological process	positive regulation of angiogenesis
GO_0061304	Biological process	retinal blood vessel morphogenesis
GO_0071373	Biological process	cellular response to luteinizing hormone stimulus
GO_0071393	Biological process	cellular response to progesterone stimulus
GO_0071387	Biological process	cellular response to cortisol stimulus
GO_1904681	Biological process	response to 3-methylcholanthrene
GO_0007155	Biological process	cell adhesion
GO_0046685	Biological process	response to arsenic-containing substance
GO_0033629	Biological process	negative regulation of cell adhesion mediated by integrin
GO_0016125	Biological process	sterol metabolic process
GO_0014911	Biological process	positive regulation of smooth muscle cell migration
GO_0032088	Biological process	negative regulation of NF-kappaB transcription factor activity
GO_0097267	Biological process	omega-hydroxylase P450 pathway
GO_0043534	Biological process	blood vessel endothelial cell migration
GO_0019373	Biological process	epoxygenase P450 pathway
GO_0071548	Biological process	response to dexamethasone
GO_0071356	Biological process	cellular response to tumor necrosis factor
GO_0071603	Biological process	endothelial cell-cell adhesion
GO_0032354	Biological process	response to follicle-stimulating hormone
GO_0071320	Biological process	cellular response to cAMP
GO_0009404	Biological process	toxin metabolic process
GO_0042574	Biological process	retinal metabolic process
GO_0043542	Biological process	endothelial cell migration
GO_2000379	Biological process	positive regulation of reactive oxygen species metabolic process
GO_0006809	Biological process	nitric oxide biosynthetic process
GO_0030325	Biological process	adrenal gland development
GO_2000573	Biological process	positive regulation of DNA biosynthetic process
GO_0042572	Biological process	retinol metabolic process
GO_0006304	Biological process	DNA modification
GO_0010575	Biological process	positive regulation of vascular endothelial growth factor production
GO_0045727	Biological process	positive regulation of translation
GO_0008210	Biological process	estrogen metabolic process
GO_0046466	Biological process	membrane lipid catabolic process
GO_0008584	Biological process	male gonad development
GO_0061548	Biological process	ganglion development
GO_0030336	Biological process	negative regulation of cell migration
GO_0097237	Biological process	cellular response to toxic substance
GO_0030199	Biological process	collagen fibril organization
GO_0048514	Biological process	blood vessel morphogenesis
GO_0002930	Biological process	trabecular meshwork development
GO_0008631	Biological process	intrinsic apoptotic signaling pathway in response to oxidative stress
GO_0008202	Biological process	steroid metabolic process
GO_0019369	Biological process	arachidonic acid metabolic process
GO_0043065	Biological process	positive regulation of apoptotic process
GO_0042537	Biological process	benzene-containing compound metabolic process
GO_0071407	Biological process	cellular response to organic cyclic compound
GO_0046427	Biological process	positive regulation of receptor signaling pathway via JAK-STAT
GO_0070301	Biological process	cellular response to hydrogen peroxide
GO_0071680	Biological process	response to indole-3-methanol
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0005739	Cellular component	mitochondrion
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0070330	Molecular function	aromatase activity
GO_0016712	Molecular function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO_0101020	Molecular function	estrogen 16-alpha-hydroxylase activity
GO_0004497	Molecular function	monooxygenase activity
GO_0005506	Molecular function	iron ion binding
GO_0020037	Molecular function	heme binding
GO_0106256	Molecular function	hydroperoxy icosatetraenoate dehydratase activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	CYP1B1
Protein name	Cytochrome p450 (EC 1.14.14.1) Cytochrome P450, family 1, subfamily B, polypeptide 1, isoform CRA_a (cDNA, FLJ93081, Homo sapiens cytochrome P450, family 1, subfamily B, polypeptide 1(CYP1B1), mRNA) Dioxin-inducible cytochrome p450 Cytochrome P450 family 1 subfamily B member 1 Truncated cytochrome P450 (EC 1.14.14.1) Cytochrome P450 1B1 (EC 1.14.14.1) (CYPIB1) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152) Mutant cytochrome p450 Cytochrome P450 1B1 Cytochrome P450 Dioxin-inducible cytochrome P450
Synonyms	hCG_14819
Description	FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) . Exhibits catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2- and 4-hydroxy E1 and E2. Displays a predominant hydroxylase activity toward E2 at the C-4 position . Metabolizes testosterone and progesterone to B or D ring hydroxylated metabolites . May act as a major enzyme for all-trans retinoic acid biosynthesis in extrahepatic tissues. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid . Catalyzes the epoxidation of double bonds of certain PUFA. Converts arachidonic acid toward epoxyeicosatrienoic acid (EpETrE) regioisomers, 8,9-, 11,12-, and 14,15- EpETrE, that function as lipid mediators in the vascular system . Additionally, displays dehydratase activity toward oxygenated eicosanoids hydroperoxyeicosatetraenoates (HpETEs). This activity is independent of cytochrome P450 reductase, NADPH, and O2 . Also involved in the oxidative metabolism of xenobiotics, particularly converting polycyclic aromatic hydrocarbons and heterocyclic aryl amines procarcinogens to DNA-damaging products . Plays an important role in retinal vascular development. Under hyperoxic O2 conditions, promotes retinal angiogenesis and capillary morphogenesis, likely by metabolizing the oxygenated products generated during the oxidative stress. Also, contributes to oxidative homeostasis and ultrastructural organization and function of trabecular meshwork tissue through modulation of POSTN expression (By similarity). .
Accessions	A0A087WW26 D0EZN8 C1KDE6 Q2EN00 D0EZN7 Q2HZ43 ENST00000610745.5 Q53TK1 ENST00000490576.1 A0A2R4CIF1 C1KDE7 Q16678 D0EZN6 C1KDE8 Q4U3K8 ENST00000494864.1 ENST00000614273.1 ENST00000490576.2 A0A087WUQ7 D0EZN5

CYP1B1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review