CYBRD1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010039Biological processresponse to iron ion
GO_0055085Biological processtransmembrane transport
GO_0060586Biological processmulticellular organismal-level iron ion homeostasis
GO_0006879Biological processintracellular iron ion homeostasis
GO_0140576Biological processascorbate homeostasis
GO_0033215Biological processreductive iron assimilation
GO_0031526Cellular componentbrush border membrane
GO_0016324Cellular componentapical plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0070062Cellular componentextracellular exosome
GO_0005765Cellular componentlysosomal membrane
GO_0140571Molecular functiontransmembrane ascorbate ferrireductase activity
GO_0042802Molecular functionidentical protein binding
GO_0016491Molecular functionoxidoreductase activity
GO_0046872Molecular functionmetal ion binding
GO_0140575Molecular functiontransmembrane monodehydroascorbate reductase activity
GO_0016722Molecular functionoxidoreductase activity, acting on metal ions
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCYBRD1
Protein namePlasma membrane ascorbate-dependent reductase CYBRD1 (EC 7.2.1.3) (Cytochrome b reductase 1)
Plasma membrane ascorbate-dependent reductase CYBRD1 (EC 7.2.1.3) (Cytochrome b reductase 1) (Duodenal cytochrome b) (Ferric-chelate reductase 3)
SynonymsDCYTB
FRRS3
DescriptionFUNCTION: Plasma membrane reductase that uses cytoplasmic ascorbate as an electron donor to reduce extracellular Fe(3+) into Fe(2+) . Probably functions in dietary iron absorption at the brush border of duodenal enterocytes by producing Fe(2+), the divalent form of iron that can be transported into enterocytes . It is also able to reduce extracellular monodehydro-L-ascorbate and may be involved in extracellular ascorbate regeneration by erythrocytes in blood . May also act as a ferrireductase in airway epithelial cells (Probable). May also function as a cupric transmembrane reductase (By similarity). .

AccessionsENST00000445146.1
C9JML1
ENST00000321348.9 [Q53TN4-1]
ENST00000375252.3 [Q53TN4-2]
ENST00000409484.5 [Q53TN4-3]
Q53TN4