Name | Number of supported studies | Average coverage | |
---|---|---|---|
fibroblast | 37 studies | 34% ± 15% | |
connective tissue cell | 12 studies | 26% ± 9% | |
type I pneumocyte | 11 studies | 37% ± 7% | |
type II pneumocyte | 9 studies | 23% ± 7% | |
pericyte | 9 studies | 19% ± 2% | |
endothelial cell | 7 studies | 21% ± 3% | |
myofibroblast cell | 7 studies | 21% ± 3% | |
enterocyte | 6 studies | 39% ± 12% | |
mesothelial cell | 6 studies | 37% ± 15% | |
smooth muscle cell | 5 studies | 19% ± 2% | |
adventitial cell | 5 studies | 38% ± 12% | |
astrocyte | 5 studies | 29% ± 9% | |
macrophage | 5 studies | 24% ± 4% | |
adipocyte | 4 studies | 28% ± 7% | |
oligodendrocyte | 4 studies | 24% ± 3% | |
abnormal cell | 3 studies | 17% ± 1% | |
epithelial cell | 3 studies | 19% ± 2% | |
muscle cell | 3 studies | 27% ± 8% | |
club cell | 3 studies | 20% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 100% | 27847.88 | 459 / 459 | 97% | 224.75 | 1079 / 1118 |
thymus | 100% | 32279.02 | 652 / 653 | 96% | 232.20 | 579 / 605 |
prostate | 96% | 11878.49 | 236 / 245 | 94% | 90.35 | 471 / 502 |
ovary | 100% | 21381.36 | 180 / 180 | 90% | 73.53 | 386 / 430 |
lung | 99% | 18660.56 | 574 / 578 | 88% | 73.46 | 1013 / 1155 |
uterus | 100% | 21165.25 | 170 / 170 | 74% | 45.30 | 338 / 459 |
skin | 99% | 18516.60 | 1798 / 1809 | 68% | 51.58 | 321 / 472 |
esophagus | 88% | 13292.91 | 1269 / 1445 | 74% | 49.92 | 135 / 183 |
bladder | 100% | 18190.67 | 21 / 21 | 53% | 27.94 | 266 / 504 |
intestine | 95% | 14928.03 | 918 / 966 | 54% | 31.37 | 286 / 527 |
adrenal gland | 96% | 14797.44 | 247 / 258 | 48% | 22.33 | 110 / 230 |
stomach | 83% | 9086.31 | 297 / 359 | 60% | 42.05 | 171 / 286 |
brain | 38% | 2291.22 | 1012 / 2642 | 90% | 61.36 | 635 / 705 |
kidney | 40% | 3122.79 | 36 / 89 | 66% | 41.90 | 598 / 901 |
adipose | 100% | 33503.05 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 35436.84 | 1335 / 1335 | 0% | 0 | 0 / 0 |
pancreas | 7% | 382.68 | 22 / 328 | 89% | 103.58 | 159 / 178 |
heart | 80% | 12215.09 | 692 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 59% | 19.37 | 17 / 29 |
tonsil | 0% | 0 | 0 / 0 | 49% | 24.01 | 22 / 45 |
eye | 0% | 0 | 0 / 0 | 38% | 18.09 | 30 / 80 |
spleen | 29% | 1676.48 | 71 / 241 | 0% | 0 | 0 / 0 |
liver | 2% | 84.73 | 4 / 226 | 22% | 9.25 | 91 / 406 |
muscle | 24% | 1531.66 | 192 / 803 | 0% | 0 | 0 / 0 |
peripheral blood | 16% | 901.52 | 153 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0010039 | Biological process | response to iron ion |
GO_0055085 | Biological process | transmembrane transport |
GO_0060586 | Biological process | multicellular organismal-level iron ion homeostasis |
GO_0006879 | Biological process | intracellular iron ion homeostasis |
GO_0140576 | Biological process | ascorbate homeostasis |
GO_0033215 | Biological process | reductive iron assimilation |
GO_0031526 | Cellular component | brush border membrane |
GO_0016324 | Cellular component | apical plasma membrane |
GO_0005886 | Cellular component | plasma membrane |
GO_0016020 | Cellular component | membrane |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005765 | Cellular component | lysosomal membrane |
GO_0140571 | Molecular function | transmembrane ascorbate ferrireductase activity |
GO_0042802 | Molecular function | identical protein binding |
GO_0016491 | Molecular function | oxidoreductase activity |
GO_0046872 | Molecular function | metal ion binding |
GO_0140575 | Molecular function | transmembrane monodehydroascorbate reductase activity |
GO_0016722 | Molecular function | oxidoreductase activity, acting on metal ions |
GO_0005515 | Molecular function | protein binding |
Gene name | CYBRD1 |
Protein name | Plasma membrane ascorbate-dependent reductase CYBRD1 (EC 7.2.1.3) (Cytochrome b reductase 1) Plasma membrane ascorbate-dependent reductase CYBRD1 (EC 7.2.1.3) (Cytochrome b reductase 1) (Duodenal cytochrome b) (Ferric-chelate reductase 3) |
Synonyms | DCYTB FRRS3 |
Description | FUNCTION: Plasma membrane reductase that uses cytoplasmic ascorbate as an electron donor to reduce extracellular Fe(3+) into Fe(2+) . Probably functions in dietary iron absorption at the brush border of duodenal enterocytes by producing Fe(2+), the divalent form of iron that can be transported into enterocytes . It is also able to reduce extracellular monodehydro-L-ascorbate and may be involved in extracellular ascorbate regeneration by erythrocytes in blood . May also act as a ferrireductase in airway epithelial cells (Probable). May also function as a cupric transmembrane reductase (By similarity). . |
Accessions | ENST00000445146.1 C9JML1 ENST00000321348.9 [Q53TN4-1] ENST00000375252.3 [Q53TN4-2] ENST00000409484.5 [Q53TN4-3] Q53TN4 |