CYB561A3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006879Biological processintracellular iron ion homeostasis
GO_0055085Biological processtransmembrane transport
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005730Cellular componentnucleolus
GO_0031902Cellular componentlate endosome membrane
GO_0005765Cellular componentlysosomal membrane
GO_0140571Molecular functiontransmembrane ascorbate ferrireductase activity
GO_0016491Molecular functionoxidoreductase activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameCYB561A3
Protein nameascorbate ferrireductase (transmembrane) (EC 7.2.1.3)
Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 (EC 7.2.1.3) (Cytochrome b ascorbate-dependent protein 3) (Cytochrome b561 family member A3) (Lysosomal cytochrome b) (LCytb)
Cytochrome b561 family member A3
Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 (EC 7.2.1.3) (Cytochrome b ascorbate-dependent protein 3) (Lysosomal cytochrome b)
SynonymsCYBASC3
PSEC0259
DescriptionFUNCTION: Transmembrane reductase that uses ascorbate as an electron donor in the cytoplasm and transfers electrons across membranes to reduce iron cations Fe(3+) into Fe(2+) in the lumen of the late endosome and lysosome. Reduced iron can then be extruded from the late endosome and lysosome to the cytoplasm by divalent metal-specific transporters. It is therefore most probably involved in endosomal and lysosomal cellular iron homeostasis. .

AccessionsENST00000540139.5
F5H240
ENST00000294072.9 [Q8NBI2-1]
F5H121
F5H5Y9
ENST00000539128.5
Q8NBI2
F5H684
ENST00000544118.5
ENST00000545361.5
ENST00000536915.5 [Q8NBI2-1]
ENST00000539890.1
F5H5L0
F5H466
ENST00000447532.6
F5GWH8
F5H832
ENST00000537364.5
ENST00000546151.5
F5GX87
ENST00000426130.6 [Q8NBI2-2]
F5H1Q2
ENST00000540755.5
F5H0P5
ENST00000537680.5
ENST00000542361.5