Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| B cell | 30 studies | 33% ± 16% | |
| plasmacytoid dendritic cell | 20 studies | 67% ± 16% | |
| memory B cell | 18 studies | 30% ± 8% | |
| naive B cell | 18 studies | 36% ± 11% | |
| ciliated cell | 7 studies | 21% ± 5% | |
| immature B cell | 6 studies | 52% ± 14% | |
| precursor B cell | 5 studies | 39% ± 17% | |
| epithelial cell | 5 studies | 23% ± 4% | |
| conventional dendritic cell | 4 studies | 35% ± 13% | |
| non-classical monocyte | 4 studies | 25% ± 5% | |
| myeloid cell | 4 studies | 29% ± 13% | |
| dendritic cell | 4 studies | 28% ± 13% | |
| classical monocyte | 3 studies | 28% ± 4% | |
| plasma cell | 3 studies | 30% ± 15% | |
| germinal center B cell | 3 studies | 42% ± 7% | |
| basal cell | 3 studies | 19% ± 1% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| peripheral blood | 3 studies | 22% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| skin | 100% | 2890.68 | 1809 / 1809 | 100% | 22.74 | 472 / 472 |
| prostate | 100% | 2015.53 | 245 / 245 | 100% | 17.28 | 500 / 502 |
| esophagus | 100% | 1598.57 | 1444 / 1445 | 99% | 8.26 | 182 / 183 |
| lung | 100% | 2210.53 | 578 / 578 | 99% | 8.53 | 1147 / 1155 |
| breast | 100% | 1845.26 | 459 / 459 | 99% | 9.03 | 1107 / 1118 |
| stomach | 100% | 1393.78 | 359 / 359 | 99% | 8.31 | 283 / 286 |
| intestine | 100% | 2259.87 | 966 / 966 | 99% | 8.59 | 520 / 527 |
| pancreas | 99% | 967.09 | 325 / 328 | 99% | 8.00 | 177 / 178 |
| ovary | 100% | 2972.34 | 180 / 180 | 98% | 7.67 | 423 / 430 |
| thymus | 100% | 1815.40 | 653 / 653 | 98% | 7.18 | 591 / 605 |
| bladder | 100% | 1831.90 | 21 / 21 | 98% | 8.52 | 492 / 504 |
| kidney | 100% | 1545.38 | 89 / 89 | 97% | 7.94 | 877 / 901 |
| uterus | 100% | 2529.35 | 170 / 170 | 97% | 7.32 | 444 / 459 |
| brain | 96% | 819.33 | 2545 / 2642 | 100% | 7.89 | 705 / 705 |
| liver | 100% | 1452.04 | 226 / 226 | 95% | 7.01 | 384 / 406 |
| adrenal gland | 100% | 27391.85 | 258 / 258 | 93% | 10.50 | 214 / 230 |
| adipose | 100% | 1969.44 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 14.58 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 54.24 | 29 / 29 |
| muscle | 100% | 1655.47 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 4642.47 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 9.41 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 5.20 | 1 / 1 |
| blood vessel | 100% | 1914.99 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| heart | 97% | 858.74 | 836 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 95% | 1751.42 | 881 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006879 | Biological process | intracellular iron ion homeostasis |
| GO_0055085 | Biological process | transmembrane transport |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0005730 | Cellular component | nucleolus |
| GO_0031902 | Cellular component | late endosome membrane |
| GO_0005765 | Cellular component | lysosomal membrane |
| GO_0140571 | Molecular function | transmembrane ascorbate ferrireductase activity |
| GO_0016491 | Molecular function | oxidoreductase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0046872 | Molecular function | metal ion binding |
| Gene name | CYB561A3 |
| Protein name | ascorbate ferrireductase (transmembrane) (EC 7.2.1.3) Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 (EC 7.2.1.3) (Cytochrome b ascorbate-dependent protein 3) (Cytochrome b561 family member A3) (Lysosomal cytochrome b) (LCytb) Cytochrome b561 family member A3 Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 (EC 7.2.1.3) (Cytochrome b ascorbate-dependent protein 3) (Lysosomal cytochrome b) |
| Synonyms | CYBASC3 PSEC0259 |
| Description | FUNCTION: Transmembrane reductase that uses ascorbate as an electron donor in the cytoplasm and transfers electrons across membranes to reduce iron cations Fe(3+) into Fe(2+) in the lumen of the late endosome and lysosome. Reduced iron can then be extruded from the late endosome and lysosome to the cytoplasm by divalent metal-specific transporters. It is therefore most probably involved in endosomal and lysosomal cellular iron homeostasis. . |
| Accessions | ENST00000540139.5 F5H240 ENST00000294072.9 [Q8NBI2-1] F5H121 F5H5Y9 ENST00000539128.5 Q8NBI2 F5H684 ENST00000544118.5 ENST00000545361.5 ENST00000536915.5 [Q8NBI2-1] ENST00000539890.1 F5H5L0 F5H466 ENST00000447532.6 F5GWH8 F5H832 ENST00000537364.5 ENST00000546151.5 F5GX87 ENST00000426130.6 [Q8NBI2-2] F5H1Q2 ENST00000540755.5 F5H0P5 ENST00000537680.5 ENST00000542361.5 |