CUL4A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0006281Biological processDNA repair
GO_0007283Biological processspermatogenesis
GO_0008283Biological processcell population proliferation
GO_0030097Biological processhemopoiesis
GO_0042254Biological processribosome biogenesis
GO_0001701Biological processin utero embryonic development
GO_0034644Biological processcellular response to UV
GO_0006974Biological processDNA damage response
GO_0140627Biological processubiquitin-dependent protein catabolic process via the C-end degron rule pathway
GO_1900087Biological processpositive regulation of G1/S transition of mitotic cell cycle
GO_0045732Biological processpositive regulation of protein catabolic process
GO_0097193Biological processintrinsic apoptotic signaling pathway
GO_0030853Biological processnegative regulation of granulocyte differentiation
GO_2000819Biological processregulation of nucleotide-excision repair
GO_0008284Biological processpositive regulation of cell population proliferation
GO_2000001Biological processregulation of DNA damage checkpoint
GO_0048511Biological processrhythmic process
GO_0042110Biological processT cell activation
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0000082Biological processG1/S transition of mitotic cell cycle
GO_0035019Biological processsomatic stem cell population maintenance
GO_0031464Cellular componentCul4A-RING E3 ubiquitin ligase complex
GO_0005654Cellular componentnucleoplasm
GO_0080008Cellular componentCul4-RING E3 ubiquitin ligase complex
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0160072Molecular functionubiquitin ligase complex scaffold activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCUL4A
Protein nameCullin 4A
Cullin-4A (CUL-4A)
Synonyms
DescriptionFUNCTION: Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins . As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme . The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 . The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component . DCX(DET1-COP1) directs ubiquitination of JUN . DCX(DDB2) directs ubiquitination of XPC . DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition during replication-coupled (H3.1) and replication-independent (H3.3) nucleosome assembly, probably by facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition . DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of p53/TP53 in response to radiation-induced DNA damage and during DNA replication . DCX(DTL) directs autoubiquitination of DTL . In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip . Is involved in ubiquitination of HOXA9 . The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 . A number of DCX complexes (containing either TRPC4AP or DCAF12 as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation . The DCX(AMBRA1) complex is a master regulator of the transition from G1 to S cell phase by mediating ubiquitination of phosphorylated cyclin-D (CCND1, CCND2 and CCND3) . The DCX(AMBRA1) complex also acts as a regulator of Cul5-RING (CRL5) E3 ubiquitin-protein ligase complexes by mediating ubiquitination and degradation of Elongin-C (ELOC) component of CRL5 complexes . With CUL4B, contributes to ribosome biogenesis . .

AccessionsA0A0A0MR50
Q13619
ENST00000375440.9 [Q13619-1]
A0A087WWN2
ENST00000451881.5 [Q13619-2]
ENST00000617546.4 [Q13619-2]
ENST00000326335.8
ENST00000375441.7 [Q13619-2]
ENST00000488558.2