Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell of proximal tubule | 9 studies | 53% ± 24% | |
| enterocyte | 4 studies | 23% ± 5% | |
| endothelial cell | 4 studies | 22% ± 5% | |
| Mueller cell | 3 studies | 20% ± 2% | |
| endothelial cell of lymphatic vessel | 3 studies | 21% ± 1% | |
| astrocyte | 3 studies | 39% ± 19% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| kidney | 4 studies | 32% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 100% | 2547.91 | 653 / 653 | 92% | 3.94 | 557 / 605 |
| kidney | 100% | 12038.56 | 89 / 89 | 86% | 80.22 | 779 / 901 |
| skin | 86% | 384.03 | 1564 / 1809 | 86% | 5.68 | 407 / 472 |
| adrenal gland | 93% | 458.02 | 240 / 258 | 43% | 0.95 | 100 / 230 |
| brain | 76% | 285.80 | 2000 / 2642 | 53% | 1.15 | 371 / 705 |
| breast | 98% | 581.76 | 450 / 459 | 14% | 0.24 | 156 / 1118 |
| uterus | 99% | 695.62 | 169 / 170 | 11% | 0.21 | 49 / 459 |
| ovary | 100% | 1472.28 | 180 / 180 | 10% | 0.21 | 43 / 430 |
| prostate | 99% | 729.46 | 243 / 245 | 8% | 0.13 | 42 / 502 |
| lung | 93% | 410.64 | 539 / 578 | 11% | 0.27 | 125 / 1155 |
| spleen | 100% | 607.05 | 241 / 241 | 0% | 0 | 0 / 0 |
| blood vessel | 98% | 573.29 | 1309 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 96% | 470.80 | 1160 / 1204 | 0% | 0 | 0 / 0 |
| bladder | 86% | 265.00 | 18 / 21 | 4% | 0.08 | 19 / 504 |
| eye | 0% | 0 | 0 / 0 | 89% | 6.09 | 71 / 80 |
| intestine | 81% | 886.29 | 779 / 966 | 3% | 0.13 | 17 / 527 |
| esophagus | 66% | 235.96 | 952 / 1445 | 8% | 0.12 | 15 / 183 |
| pancreas | 57% | 142.91 | 188 / 328 | 13% | 0.20 | 24 / 178 |
| stomach | 57% | 163.45 | 204 / 359 | 5% | 0.09 | 15 / 286 |
| heart | 46% | 147.77 | 398 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 21% | 52.82 | 191 / 929 | 0% | 0 | 0 / 0 |
| muscle | 11% | 26.09 | 90 / 803 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 3% | 0.04 | 1 / 29 |
| liver | 1% | 1.63 | 2 / 226 | 2% | 0.06 | 9 / 406 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0006898 | Biological process | receptor-mediated endocytosis |
| GO_0009617 | Biological process | response to bacterium |
| GO_0015889 | Biological process | cobalamin transport |
| GO_0008203 | Biological process | cholesterol metabolic process |
| GO_0009235 | Biological process | cobalamin metabolic process |
| GO_0051649 | Biological process | establishment of localization in cell |
| GO_0042953 | Biological process | lipoprotein transport |
| GO_0001894 | Biological process | tissue homeostasis |
| GO_0031526 | Cellular component | brush border membrane |
| GO_0016324 | Cellular component | apical plasma membrane |
| GO_0043235 | Cellular component | receptor complex |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0030139 | Cellular component | endocytic vesicle |
| GO_0016020 | Cellular component | membrane |
| GO_0031528 | Cellular component | microvillus membrane |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0005794 | Cellular component | Golgi apparatus |
| GO_0031232 | Cellular component | extrinsic component of external side of plasma membrane |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0005829 | Cellular component | cytosol |
| GO_0005905 | Cellular component | clathrin-coated pit |
| GO_0043202 | Cellular component | lysosomal lumen |
| GO_0005768 | Cellular component | endosome |
| GO_0005765 | Cellular component | lysosomal membrane |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0038023 | Molecular function | signaling receptor activity |
| GO_0031419 | Molecular function | cobalamin binding |
| GO_0038024 | Molecular function | cargo receptor activity |
| GO_0005509 | Molecular function | calcium ion binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | CUBN |
| Protein name | Intrinsic factor-vitamin B12 receptor Cubilin variant 3 Cubilin (460 kDa receptor) (Intestinal intrinsic factor receptor) (Intrinsic factor-cobalamin receptor) (Intrinsic factor-vitamin B12 receptor) Cubilin |
| Synonyms | IFCR |
| Description | FUNCTION: Endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake . Acts together with LRP2 to mediate endocytosis of high-density lipoproteins, GC, hemoglobin, ALB, TF and SCGB1A1. Acts together with AMN to mediate endocytosis of the CBLIF-cobalamin complex . Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the CBLIF-cobalamin complex. Ligand binding requires calcium . Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface. . |
| Accessions | ENST00000377833.10 ENST00000433666.5 B0YIZ6 Q7LC53 O60494 Q96RV0 H7C480 |
