Name | Number of supported studies | Average coverage | |
---|---|---|---|
astrocyte | 20 studies | 72% ± 24% | |
oligodendrocyte precursor cell | 15 studies | 71% ± 23% | |
glutamatergic neuron | 13 studies | 80% ± 21% | |
GABAergic neuron | 11 studies | 78% ± 23% | |
oligodendrocyte | 11 studies | 37% ± 20% | |
microglial cell | 10 studies | 37% ± 17% | |
neuron | 8 studies | 53% ± 24% | |
endothelial cell | 7 studies | 45% ± 17% | |
interneuron | 7 studies | 68% ± 25% | |
retinal ganglion cell | 6 studies | 67% ± 33% | |
Mueller cell | 6 studies | 71% ± 28% | |
granule cell | 4 studies | 64% ± 20% | |
amacrine cell | 4 studies | 45% ± 30% | |
GABAergic interneuron | 3 studies | 84% ± 1% | |
GABAergic amacrine cell | 3 studies | 75% ± 17% | |
OFF-bipolar cell | 3 studies | 73% ± 12% | |
ON-bipolar cell | 3 studies | 90% ± 4% | |
glycinergic amacrine cell | 3 studies | 59% ± 20% | |
ependymal cell | 3 studies | 82% ± 8% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 6625.19 | 2633 / 2642 | 99% | 54.07 | 698 / 705 |
adrenal gland | 4% | 34.00 | 10 / 258 | 73% | 12.90 | 167 / 230 |
ovary | 0% | 0 | 0 / 180 | 26% | 2.47 | 113 / 430 |
skin | 0% | 0.27 | 1 / 1809 | 26% | 2.70 | 123 / 472 |
intestine | 11% | 67.95 | 103 / 966 | 4% | 0.45 | 23 / 527 |
liver | 0% | 0 | 0 / 226 | 14% | 2.54 | 56 / 406 |
uterus | 2% | 15.91 | 3 / 170 | 9% | 0.93 | 40 / 459 |
stomach | 1% | 7.73 | 5 / 359 | 6% | 1.71 | 16 / 286 |
pancreas | 3% | 17.09 | 10 / 328 | 4% | 0.36 | 7 / 178 |
lymph node | 0% | 0 | 0 / 0 | 7% | 0.71 | 2 / 29 |
kidney | 0% | 0 | 0 / 89 | 5% | 0.60 | 46 / 901 |
eye | 0% | 0 | 0 / 0 | 5% | 0.82 | 4 / 80 |
breast | 0% | 0 | 0 / 459 | 3% | 0.38 | 31 / 1118 |
prostate | 1% | 5.05 | 2 / 245 | 2% | 0.11 | 9 / 502 |
bladder | 0% | 0 | 0 / 21 | 2% | 0.22 | 12 / 504 |
esophagus | 1% | 4.85 | 12 / 1445 | 1% | 0.26 | 2 / 183 |
lung | 0% | 0 | 0 / 578 | 1% | 0.21 | 13 / 1155 |
thymus | 0% | 0 | 0 / 653 | 1% | 0.03 | 4 / 605 |
peripheral blood | 0% | 3.31 | 3 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
adipose | 0% | 0 | 0 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 0% | 0 | 0 / 1335 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
heart | 0% | 0 | 0 / 861 | 0% | 0 | 0 / 0 |
muscle | 0% | 0 | 0 / 803 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0034316 | Biological process | negative regulation of Arp2/3 complex-mediated actin nucleation |
GO_2001222 | Biological process | regulation of neuron migration |
GO_0048813 | Biological process | dendrite morphogenesis |
GO_0021942 | Biological process | radial glia guided migration of Purkinje cell |
GO_0051823 | Biological process | regulation of synapse structural plasticity |
GO_0007010 | Biological process | cytoskeleton organization |
GO_0007409 | Biological process | axonogenesis |
GO_0048854 | Biological process | brain morphogenesis |
GO_0010975 | Biological process | regulation of neuron projection development |
GO_0060134 | Biological process | prepulse inhibition |
GO_0098609 | Biological process | cell-cell adhesion |
GO_0016477 | Biological process | cell migration |
GO_0016342 | Cellular component | catenin complex |
GO_0015629 | Cellular component | actin cytoskeleton |
GO_0005829 | Cellular component | cytosol |
GO_0005912 | Cellular component | adherens junction |
GO_0005737 | Cellular component | cytoplasm |
GO_0030424 | Cellular component | axon |
GO_0005634 | Cellular component | nucleus |
GO_0045296 | Molecular function | cadherin binding |
GO_0005200 | Molecular function | structural constituent of cytoskeleton |
GO_0051015 | Molecular function | actin filament binding |
GO_0008013 | Molecular function | beta-catenin binding |
GO_0005515 | Molecular function | protein binding |
Gene name | CTNNA2 |
Protein name | Catenin alpha 2 Catenin alpha-2 (Alpha N-catenin) (Alpha-catenin-related protein) Catenin alpha-2 (Alpha N-catenin) |
Synonyms | CAPR |
Description | FUNCTION: May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system (By similarity). Required for proper regulation of cortical neuronal migration and neurite growth . It acts as a negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization . It thereby suppresses excessive actin branching which would impair neurite growth and stability . Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity). . |
Accessions | B8ZZE7 C9IZ88 ENST00000451966.5 ENST00000361291.8 ENST00000540488.5 ENST00000409971.6 F6KRI5 ENST00000409550.2 B9A010 ENST00000343114.7 [P26232-6] ENST00000409266.5 A0A0A0MTJ6 C9J144 A0A0A0MRI5 ENST00000496558.5 [P26232-2] ENST00000402739.9 [P26232-1] ENST00000541047.5 [P26232-4] ENST00000629316.2 [P26232-3] P26232 ENST00000466387.5 [P26232-2] Q49AD3 |