CTIF report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006446Biological processregulation of translational initiation
GO_0000184Biological processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO_0045727Biological processpositive regulation of translation
GO_0005829Cellular componentcytosol
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005515Molecular functionprotein binding
GO_0003723Molecular functionRNA binding
GO_0008494Molecular functiontranslation activator activity

IV. Literature review

[source]
Gene nameCTIF
Protein nameCBP80/20-dependent translation initiation factor (Cap binding complex dependent translation initiation factor)
CBP80/20-dependent translation initiation factor
SynonymsKIAA0427
DescriptionFUNCTION: Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after mRNA export via the nuclear pore complex (NPC). Acts via its interaction with the NCBP1/CBP80 component of the CBC complex and recruits the 40S small subunit of the ribosome via eIF3. In contrast, it is not involved in steady state translation, that takes place when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD), the pioneer round of mRNA translation mediated by the cap-binding complex playing a central role in nonsense-mediated mRNA decay (NMD). .

AccessionsENST00000634350.1 [O43310-2]
ENST00000588345.1
ENST00000587752.5
ENST00000635228.2 [O43310-1]
ENST00000382998.8 [O43310-2]
ENST00000591387.5
ENST00000634324
ENST00000635283
ENST00000591412.5
ENST00000256413.8 [O43310-1]
K7EQS5
ENST00000635367
K7EPK6
ENST00000634755
O43310
K7EQS9
K7EK08