CTDSP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000134Biological processnegative regulation of G1/S transition of mitotic cell cycle
GO_0001933Biological processnegative regulation of protein phosphorylation
GO_0045665Biological processnegative regulation of neuron differentiation
GO_0006470Biological processprotein dephosphorylation
GO_0050768Biological processnegative regulation of neurogenesis
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0008420Molecular functionRNA polymerase II CTD heptapeptide repeat phosphatase activity
GO_0005515Molecular functionprotein binding
GO_0017018Molecular functionmyosin phosphatase activity
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameCTDSP1
Protein nameprotein-serine/threonine phosphatase (EC 3.1.3.16)
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 (EC 3.1.3.16) (Nuclear LIM interactor-interacting factor 3) (NLI-IF) (NLI-interacting factor 3) (Small C-terminal domain phosphatase 1) (SCP1) (Small CTD phosphatase 1)
CTD small phosphatase 1
SynonymsSCP1
NLIIF
NIF3
DescriptionFUNCTION: Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. .

AccessionsENST00000473420.6
ENST00000491064.6
ENST00000498160.6
ENST00000710839.1
ENST00000464255.2
ENST00000710838.1
ENST00000452977.6
ENST00000428361.6
ENST00000488627.6
ENST00000710828.1
ENST00000273062.7 [Q9GZU7-1]
A0AA34QW09
ENST00000443891.6
ENST00000710837.1 [Q9GZU7-2]
A0AA34QVU0
H7C270
Q9GZU7