CRHR1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CRHR1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CRHR1 at tissue level.

III. Associated gene sets

GO_0071376Biological processcellular response to corticotropin-releasing hormone stimulus
GO_0010578Biological processregulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway
GO_0035640Biological processexploration behavior
GO_0051867Biological processgeneral adaptation syndrome, behavioral process
GO_0048149Biological processbehavioral response to ethanol
GO_1901386Biological processnegative regulation of voltage-gated calcium channel activity
GO_2000852Biological processregulation of corticosterone secretion
GO_0007565Biological processfemale pregnancy
GO_0051458Biological processcorticotropin secretion
GO_0042596Biological processfear response
GO_0006955Biological processimmune response
GO_0007190Biological processactivation of adenylate cyclase activity
GO_0030325Biological processadrenal gland development
GO_0007189Biological processadenylate cyclase-activating G protein-coupled receptor signaling pathway
GO_0007567Biological processparturition
GO_0007166Biological processcell surface receptor signaling pathway
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0043005Cellular componentneuron projection
GO_0005768Cellular componentendosome
GO_0043404Molecular functioncorticotropin-releasing hormone receptor activity
GO_0008528Molecular functionG protein-coupled peptide receptor activity
GO_0051424Molecular functioncorticotropin-releasing hormone binding
GO_0005515Molecular functionprotein binding
GO_0015056Molecular functioncorticotrophin-releasing factor receptor activity

IV. Literature review

[source]
Gene nameCRHR1
Protein nameCorticotropin-releasing factor receptor 1 (CRF-R-1) (CRF-R1) (CRFR-1) (Corticotropin-releasing hormone receptor 1) (CRH-R-1) (CRH-R1)
Corticotropin releasing hormone receptor variant 1f
Corticotropin releasing hormone receptor variant 1e
Corticotropin releasing hormone receptor 1 (Corticotropin-releasing factor receptor 1)
CRF1 receptor isoform I variant B (Corticotropin-releasing factor receptor 1)
Corticotropin-releasing factor receptor 1
Corticotropin releasing hormone receptor variant 1g
Corticotropin releasing hormone receptor 1
CRH receptor 1 variant B (Corticotropin releasing hormone receptor 1) (Corticotropin-releasing factor receptor 1)
Corticotropin-releasing factor receptor 1 isoform j
CRF1 receptor isoform I (Corticotropin releasing hormone receptor 1)
SynonymsCRFR
CRFR1
CRHR
DescriptionFUNCTION: G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli. .

FUNCTION: G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli. .

FUNCTION: G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli. .

AccessionsB3SXS2
ENST00000632957.1
ENST00000619154.4
ENST00000352855.9 [P34998-3]
Q8NFN9
ENST00000577353.5 [P34998-4]
A0A994J7T2
ENST00000632552.1
ENST00000611599.1
ENST00000347197.9
ENST00000633333.1
P34998
ENST00000617446.1
ENST00000632383.1
ENST00000616225.3
ENST00000613260.4 [P34998-1]
J3KSM0
K9J956
Q8WXR7
A0A1U6XTF7
A0A0A0MQZ1
H0YFR5
ENST00000314537.10 [P34998-2]
J3QQR1
ENST00000580876.6
ENST00000705341.1
ENST00000631395.1
ENST00000621969.2
ENST00000618144.2
ENST00000339069.9
ENST00000617905.4 [P34998-2]
A0A0G2JM19
ENST00000616274.4 [P34998-1]
ENST00000615345.4 [P34998-3]
ENST00000614143.4
Q8WXR5
ENST00000398285.7 [P34998-1]
J3QKP8
ENST00000616748.4 [P34998-3]
B3TIK8
A0A994J7S2
ENST00000633723.1 [P34998-4]
J9JIC6
Q8WXR6
ENST00000618382.4 [P34998-2]