Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 8 studies | 34% ± 16% | |
| type I pneumocyte | 5 studies | 24% ± 9% | |
| secretory cell | 5 studies | 28% ± 8% | |
| type II pneumocyte | 4 studies | 27% ± 14% | |
| ciliated cell | 4 studies | 28% ± 9% |
Insufficient scRNA-seq data for expression of CRB3 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| pancreas | 100% | 847.38 | 328 / 328 | 98% | 45.25 | 175 / 178 |
| kidney | 100% | 1128.83 | 89 / 89 | 96% | 47.14 | 869 / 901 |
| liver | 100% | 582.16 | 226 / 226 | 96% | 29.26 | 390 / 406 |
| lung | 95% | 711.20 | 551 / 578 | 98% | 42.85 | 1131 / 1155 |
| thymus | 99% | 698.86 | 649 / 653 | 90% | 44.25 | 545 / 605 |
| prostate | 84% | 362.64 | 206 / 245 | 99% | 46.96 | 496 / 502 |
| stomach | 75% | 806.70 | 270 / 359 | 97% | 58.17 | 278 / 286 |
| breast | 52% | 189.54 | 239 / 459 | 98% | 35.46 | 1093 / 1118 |
| intestine | 46% | 561.24 | 446 / 966 | 98% | 67.59 | 518 / 527 |
| esophagus | 39% | 631.18 | 570 / 1445 | 97% | 34.89 | 177 / 183 |
| bladder | 38% | 198.48 | 8 / 21 | 93% | 50.88 | 470 / 504 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 44.33 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 27.07 | 1 / 1 |
| ovary | 1% | 1.68 | 2 / 180 | 99% | 40.65 | 424 / 430 |
| uterus | 6% | 25.22 | 10 / 170 | 86% | 38.41 | 397 / 459 |
| skin | 72% | 1028.41 | 1304 / 1809 | 3% | 0.54 | 16 / 472 |
| lymph node | 0% | 0 | 0 / 0 | 31% | 4.95 | 9 / 29 |
| peripheral blood | 4% | 7.15 | 33 / 929 | 0% | 0 | 0 / 0 |
| adrenal gland | 0% | 0.62 | 1 / 258 | 1% | 0.49 | 2 / 230 |
| eye | 0% | 0 | 0 / 0 | 1% | 0.11 | 1 / 80 |
| adipose | 1% | 2.99 | 15 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0.80 | 1 / 241 | 0% | 0 | 0 / 0 |
| muscle | 0% | 0.37 | 2 / 803 | 0% | 0 | 0 / 0 |
| blood vessel | 0% | 0.75 | 2 / 1335 | 0% | 0 | 0 / 0 |
| heart | 0% | 0.15 | 1 / 861 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| brain | 0% | 0 | 0 / 2642 | 0% | 0 | 0 / 705 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_1901890 | Biological process | positive regulation of cell junction assembly |
| GO_0045197 | Biological process | establishment or maintenance of epithelial cell apical/basal polarity |
| GO_0072659 | Biological process | protein localization to plasma membrane |
| GO_0016324 | Cellular component | apical plasma membrane |
| GO_0035003 | Cellular component | subapical complex |
| GO_0030054 | Cellular component | cell junction |
| GO_0043296 | Cellular component | apical junction complex |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005923 | Cellular component | bicellular tight junction |
| GO_0019904 | Molecular function | protein domain specific binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0017124 | Molecular function | SH3 domain binding |
| Gene name | CRB3 |
| Protein name | Protein crumbs homolog 3 |
| Synonyms | UNQ588/PRO1158 |
| Description | FUNCTION: Involved in the establishment of cell polarity in mammalian epithelial cells . Regulates the morphogenesis of tight junctions . Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7 (By similarity). . |
| Accessions | ENST00000356762.7 [Q9BUF7-2] ENST00000600229.6 [Q9BUF7-1] Q9BUF7 ENST00000308243.7 [Q9BUF7-1] ENST00000598494.5 [Q9BUF7-1] |
