CRACR2A report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CRACR2A at tissue level.

III. Associated gene sets

GO_0032237Biological processactivation of store-operated calcium channel activity
GO_0002250Biological processadaptive immune response
GO_0051928Biological processpositive regulation of calcium ion transport
GO_0002115Biological processstore-operated calcium entry
GO_0005815Cellular componentmicrotubule organizing center
GO_0000139Cellular componentGolgi membrane
GO_0005576Cellular componentextracellular region
GO_0016020Cellular componentmembrane
GO_0005886Cellular componentplasma membrane
GO_0035580Cellular componentspecific granule lumen
GO_0005737Cellular componentcytoplasm
GO_0005525Molecular functionGTP binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameCRACR2A
Protein nameEF-hand calcium-binding domain-containing protein 4B (Calcium release-activated calcium channel regulator 2A) (CRAC channel regulator 2A) (Calcium release-activated channel regulator 2A) (Ras-related protein Rab-46)
Calcium release activated channel regulator 2A
SynonymsEFCAB4B
RAB46
DescriptionFUNCTION: [Isoform 1]: Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex. .; FUNCTION: [Isoform 2]: Rab GTPase that mediates the trafficking of Weibel-Palade bodies (WPBs) to microtubule organizing center (MTOC) in endothelial cells in response to acute inflammatory stimuli . During histamine (but not thrombin) stimulation of endothelial cells, the dynein-bound form induces retrograde transport of a subset of WPBs along microtubules to the MTOC in a Ca(2+)-independent manner and its GTPase activity is essential for this function . Ca(2+)-regulated dynein adapter protein that activates dynein-mediated transport and dynein-dynactin motility on microtubules and regulates endosomal trafficking of CD47 . Acts as an intracellular signaling module bridging two important T-cell receptor (TCR) signaling pathways, Ca(2+)-NFAT and JNK, to affect T-cell activation . In resting T-cells, is predominantly localized near TGN network in a GTP-bound form, upon TCR stimulation, localizes at the immunological synapse via interaction with VAV1 to activate downstream Ca(2+)-NFAT and JNK signaling pathways . Plays a role in T-helper 1 (Th1) cell differentiation and T-helper 17 (Th17) cell effector function . Plays a role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation . .

AccessionsH0YFI5
ENST00000440314.7 [Q9BSW2-2]
ENST00000252322.1 [Q9BSW2-1]
Q9BSW2
ENST00000535292.1
ENST00000333750.9
H7BXT2