Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 5 studies | 41% ± 20% | |
| GABAergic neuron | 5 studies | 32% ± 17% | |
| oligodendrocyte precursor cell | 3 studies | 24% ± 2% | |
| interneuron | 3 studies | 30% ± 15% | |
| neuron | 3 studies | 27% ± 4% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 4 studies | 33% ± 14% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 100% | 3681.68 | 2641 / 2642 | 100% | 33.61 | 705 / 705 |
| ovary | 96% | 874.59 | 172 / 180 | 66% | 5.53 | 283 / 430 |
| uterus | 99% | 1359.44 | 169 / 170 | 59% | 7.10 | 269 / 459 |
| adrenal gland | 28% | 178.43 | 71 / 258 | 78% | 27.49 | 180 / 230 |
| prostate | 86% | 618.50 | 211 / 245 | 19% | 0.56 | 94 / 502 |
| breast | 56% | 281.59 | 255 / 459 | 47% | 1.95 | 526 / 1118 |
| skin | 38% | 354.63 | 687 / 1809 | 59% | 4.12 | 278 / 472 |
| thymus | 67% | 359.45 | 440 / 653 | 29% | 1.79 | 173 / 605 |
| spleen | 96% | 905.70 | 231 / 241 | 0% | 0 | 0 / 0 |
| lung | 46% | 252.98 | 266 / 578 | 47% | 2.76 | 539 / 1155 |
| pancreas | 5% | 23.84 | 18 / 328 | 87% | 6.21 | 155 / 178 |
| bladder | 52% | 402.10 | 11 / 21 | 40% | 2.89 | 201 / 504 |
| esophagus | 35% | 189.59 | 506 / 1445 | 47% | 2.27 | 86 / 183 |
| intestine | 51% | 296.41 | 496 / 966 | 19% | 1.10 | 101 / 527 |
| stomach | 25% | 132.23 | 91 / 359 | 30% | 1.69 | 86 / 286 |
| kidney | 25% | 119.27 | 22 / 89 | 29% | 1.14 | 263 / 901 |
| tonsil | 0% | 0 | 0 / 0 | 53% | 2.92 | 24 / 45 |
| adipose | 46% | 292.31 | 554 / 1204 | 0% | 0 | 0 / 0 |
| heart | 41% | 237.18 | 354 / 861 | 0% | 0 | 0 / 0 |
| blood vessel | 32% | 177.93 | 426 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 24% | 0.72 | 7 / 29 |
| eye | 0% | 0 | 0 / 0 | 19% | 0.91 | 15 / 80 |
| liver | 1% | 7.42 | 3 / 226 | 10% | 0.45 | 41 / 406 |
| muscle | 0% | 0.97 | 2 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0.38 | 1 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0098734 | Biological process | macromolecule depalmitoylation |
| GO_0009437 | Biological process | carnitine metabolic process |
| GO_0099072 | Biological process | regulation of postsynaptic membrane neurotransmitter receptor levels |
| GO_0006631 | Biological process | fatty acid metabolic process |
| GO_0098978 | Cellular component | glutamatergic synapse |
| GO_0030424 | Cellular component | axon |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0030425 | Cellular component | dendrite |
| GO_0032281 | Cellular component | AMPA glutamate receptor complex |
| GO_0098794 | Cellular component | postsynapse |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0005515 | Molecular function | protein binding |
| GO_0004095 | Molecular function | carnitine O-palmitoyltransferase activity |
| GO_0008474 | Molecular function | palmitoyl-(protein) hydrolase activity |
| Gene name | CPT1C |
| Protein name | Carnitine palmitoyltransferase 1C, isoform CRA_d (cDNA FLJ39197 fis, clone OCBBF2005077, highly similar to Carnitine O-palmitoyltransferase I, brain isoform) Palmitoyl thioesterase CPT1C (EC 3.1.2.22) (Carnitine O-palmitoyltransferase 1, brain isoform) (CPTI-B) (Carnitine palmitoyltransferase 1C) (Carnitine palmitoyltransferase I) (CPT I-C) Carnitine palmitoyltransferase 1C |
| Synonyms | hCG_2039825 CATL1 |
| Description | FUNCTION: Palmitoyl thioesterase specifically expressed in the endoplasmic reticulum of neurons. Modulates the trafficking of the glutamate receptor, AMPAR, to plasma membrane through depalmitoylation of GRIA1 . Also regulates AMPR trafficking through the regulation of SACM1L phosphatidylinositol-3-phosphatase activity by interaction in a malonyl-CoA dependent manner (By similarity). Binds malonyl-CoA and couples malonyl-CoA to ceramide levels, necessary for proper spine maturation and contributing to systemic energy homeostasis and appetite control . Binds to palmitoyl-CoA, but does not have carnitine palmitoyltransferase 1 catalytic activity or at very low levels . . |
| Accessions | ENST00000405931.6 [Q8TCG5-2] ENST00000594038.5 ENST00000596922.5 ENST00000597099.1 M0R2H6 ENST00000594587.5 B3KU49 ENST00000323446.9 [Q8TCG5-1] ENST00000602019.5 M0R2B9 ENST00000595568.5 M0R1F9 ENST00000595031.1 ENST00000598293.6 [Q8TCG5-1] M0R2V3 ENST00000598396.5 ENST00000598259.5 M0R115 M0R0D3 ENST00000392518.8 [Q8TCG5-1] Q8TCG5 M0R399 ENST00000595969.5 M0QZ13 |
