CPSF3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1900087Biological processpositive regulation of G1/S transition of mitotic cell cycle
GO_0006398Biological processmRNA 3'-end processing by stem-loop binding and cleavage
GO_0180010Biological processco-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway
GO_0031124Biological processmRNA 3'-end processing
GO_0005847Cellular componentmRNA cleavage and polyadenylation specificity factor complex
GO_0005654Cellular componentnucleoplasm
GO_1990904Cellular componentribonucleoprotein complex
GO_0004534Molecular function5'-3' RNA exonuclease activity
GO_0004521Molecular functionRNA endonuclease activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameCPSF3
Protein nameCPSF3 protein
Cleavage and polyadenylation specificity factor subunit 3 (EC 3.1.27.-) (Cleavage and polyadenylation specificity factor 73 kDa subunit) (CPSF 73 kDa subunit) (mRNA 3'-end-processing endonuclease CPSF-73)
Cleavage and polyadenylation specific factor 3
SynonymsCPSF73
hCG_1784298
DescriptionFUNCTION: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as an mRNA 3'-end-processing endonuclease . Also involved in the histone 3'-end pre-mRNA processing . U7 snRNP-dependent protein that induces both the 3'-endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5' to 3' exonuclease for degrading the subsequent downstream cleavage product (DCP) of mature histone mRNAs. Cleavage occurs after the 5'-ACCCA-3' sequence in the histone pre-mRNA leaving a 3'hydroxyl group on the upstream fragment containing the stem loop (SL) and 5' phosphate on the downstream cleavage product (DCP) starting with CU nucleotides. The U7-dependent 5' to 3' exonuclease activity is processive and degrades the DCP RNA substrate even after complete removal of the U7-binding site. Binds to the downstream cleavage product (DCP) of histone pre-mRNAs and the cleaved DCP RNA substrate in a U7 snRNP dependent manner. Required for entering/progressing through S-phase of the cell cycle . Required for the selective processing of microRNAs (miRNAs) during embryonic stem cell differentiation via its interaction with ISY1 (By similarity). Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a (By similarity). Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively (By similarity). .

AccessionsG5E9W3
ENST00000238112.8
C9JZH6
Q9UKF6
ENST00000475482.5
ENST00000460593.1
Q05BZ5