COX7A1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1902600Biological processproton transmembrane transport
GO_0097250Biological processmitochondrial respirasome assembly
GO_0006091Biological processgeneration of precursor metabolites and energy
GO_0006123Biological processmitochondrial electron transport, cytochrome c to oxygen
GO_0002082Biological processregulation of oxidative phosphorylation
GO_0005751Cellular componentmitochondrial respiratory chain complex IV
GO_0005746Cellular componentmitochondrial respirasome
GO_0005739Cellular componentmitochondrion
GO_0004129Molecular functioncytochrome-c oxidase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCOX7A1
Protein nameCytochrome c oxidase subunit 7A1, mitochondrial (Cytochrome c oxidase subunit VIIa-heart)
Cytochrome c oxidase subunit 7A1
Cytochrome c oxidase subunit 7A1, mitochondrial (Cytochrome c oxidase subunit VIIa-heart) (Cytochrome c oxidase subunit VIIa-H) (Cytochrome c oxidase subunit VIIa-muscle) (Cytochrome c oxidase subunit VIIa-M)
SynonymsCOX7AH
DescriptionFUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. .

AccessionsQ6FGI7
P24310
H6SG12
ENST00000292907.8
ENST00000437291.6
K7ER11
U3KQH8
ENST00000589154.1