Name | Number of supported studies | Average coverage | |
---|---|---|---|
fibroblast | 31 studies | 33% ± 14% | |
pericyte | 29 studies | 43% ± 17% | |
endothelial cell | 27 studies | 36% ± 15% | |
smooth muscle cell | 22 studies | 43% ± 17% | |
endothelial cell of lymphatic vessel | 16 studies | 39% ± 12% | |
capillary endothelial cell | 14 studies | 31% ± 10% | |
myofibroblast cell | 13 studies | 29% ± 10% | |
connective tissue cell | 11 studies | 32% ± 9% | |
endothelial cell of artery | 10 studies | 30% ± 7% | |
vein endothelial cell | 10 studies | 29% ± 7% | |
endothelial cell of vascular tree | 7 studies | 36% ± 5% | |
kidney loop of Henle epithelial cell | 5 studies | 33% ± 13% | |
renal alpha-intercalated cell | 5 studies | 58% ± 6% | |
cardiac muscle cell | 5 studies | 34% ± 18% | |
glomerular endothelial cell | 4 studies | 51% ± 6% | |
retinal ganglion cell | 4 studies | 42% ± 15% | |
amacrine cell | 4 studies | 29% ± 8% | |
adventitial cell | 4 studies | 23% ± 7% | |
pancreatic A cell | 3 studies | 19% ± 2% | |
retinal bipolar neuron | 3 studies | 42% ± 20% | |
OFF-bipolar cell | 3 studies | 31% ± 9% | |
retina horizontal cell | 3 studies | 33% ± 7% | |
retinal rod cell | 3 studies | 22% ± 5% | |
muscle cell | 3 studies | 46% ± 24% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
adrenal gland | 97% | 1541.89 | 250 / 258 | 97% | 339.61 | 223 / 230 |
prostate | 89% | 1487.22 | 217 / 245 | 94% | 68.26 | 474 / 502 |
thymus | 88% | 1123.84 | 576 / 653 | 93% | 155.30 | 565 / 605 |
breast | 97% | 2030.97 | 446 / 459 | 82% | 40.40 | 916 / 1118 |
lung | 91% | 1265.28 | 525 / 578 | 73% | 23.01 | 848 / 1155 |
kidney | 81% | 1102.87 | 72 / 89 | 79% | 127.17 | 715 / 901 |
bladder | 86% | 1879.67 | 18 / 21 | 64% | 25.27 | 325 / 504 |
brain | 63% | 766.31 | 1665 / 2642 | 81% | 52.91 | 571 / 705 |
uterus | 94% | 1339.21 | 159 / 170 | 48% | 35.33 | 219 / 459 |
intestine | 72% | 1680.81 | 696 / 966 | 67% | 21.38 | 355 / 527 |
esophagus | 69% | 2392.83 | 1001 / 1445 | 55% | 15.38 | 100 / 183 |
ovary | 79% | 887.88 | 142 / 180 | 31% | 8.37 | 134 / 430 |
stomach | 36% | 719.85 | 130 / 359 | 70% | 23.32 | 199 / 286 |
heart | 100% | 19467.30 | 861 / 861 | 0% | 0 | 0 / 0 |
muscle | 100% | 21089.95 | 803 / 803 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 26.04 | 1 / 1 |
blood vessel | 100% | 3358.82 | 1332 / 1335 | 0% | 0 | 0 / 0 |
adipose | 99% | 2414.68 | 1197 / 1204 | 0% | 0 | 0 / 0 |
pancreas | 3% | 21.34 | 9 / 328 | 96% | 70.49 | 170 / 178 |
skin | 36% | 344.84 | 660 / 1809 | 41% | 23.64 | 195 / 472 |
lymph node | 0% | 0 | 0 / 0 | 72% | 24.23 | 21 / 29 |
eye | 0% | 0 | 0 / 0 | 56% | 20.65 | 45 / 80 |
spleen | 49% | 453.54 | 118 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 47% | 13.67 | 21 / 45 |
liver | 0% | 2.87 | 1 / 226 | 38% | 24.43 | 155 / 406 |
peripheral blood | 1% | 17.99 | 10 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_1902600 | Biological process | proton transmembrane transport |
GO_0097250 | Biological process | mitochondrial respirasome assembly |
GO_0006091 | Biological process | generation of precursor metabolites and energy |
GO_0006123 | Biological process | mitochondrial electron transport, cytochrome c to oxygen |
GO_0002082 | Biological process | regulation of oxidative phosphorylation |
GO_0005751 | Cellular component | mitochondrial respiratory chain complex IV |
GO_0005746 | Cellular component | mitochondrial respirasome |
GO_0005739 | Cellular component | mitochondrion |
GO_0004129 | Molecular function | cytochrome-c oxidase activity |
GO_0005515 | Molecular function | protein binding |
Gene name | COX7A1 |
Protein name | Cytochrome c oxidase subunit 7A1, mitochondrial (Cytochrome c oxidase subunit VIIa-heart) Cytochrome c oxidase subunit 7A1 Cytochrome c oxidase subunit 7A1, mitochondrial (Cytochrome c oxidase subunit VIIa-heart) (Cytochrome c oxidase subunit VIIa-H) (Cytochrome c oxidase subunit VIIa-muscle) (Cytochrome c oxidase subunit VIIa-M) |
Synonyms | COX7AH |
Description | FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. . |
Accessions | Q6FGI7 P24310 H6SG12 ENST00000292907.8 ENST00000437291.6 K7ER11 U3KQH8 ENST00000589154.1 |