COBL report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1900029Biological processpositive regulation of ruffle assembly
GO_0030041Biological processactin filament polymerization
GO_0048669Biological processcollateral sprouting in absence of injury
GO_0001889Biological processliver development
GO_0001757Biological processsomite specification
GO_0051639Biological processactin filament network formation
GO_1900006Biological processpositive regulation of dendrite development
GO_0001843Biological processneural tube closure
GO_0048565Biological processdigestive tract development
GO_0000578Biological processembryonic axis specification
GO_0030903Biological processnotochord development
GO_0033504Biological processfloor plate development
GO_0001726Cellular componentruffle
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0043025Cellular componentneuronal cell body
GO_0005884Cellular componentactin filament
GO_0030425Cellular componentdendrite
GO_1990357Cellular componentterminal web
GO_0044294Cellular componentdendritic growth cone
GO_0005938Cellular componentcell cortex
GO_0044295Cellular componentaxonal growth cone
GO_0030424Cellular componentaxon
GO_0003785Molecular functionactin monomer binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCOBL
Protein nameAlternative protein COBL
Cordon-bleu WH2 repeat protein
Protein cordon-bleu
SynonymsKIAA0633
DescriptionFUNCTION: Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. .

AccessionsO75128
ENST00000265136.12 [O75128-1]
C9J9X1
ENST00000395542.6 [O75128-7]
J3KR05
H7C1N2
ENST00000445054.5
A0A3B3IU00
ENST00000431948.5
ENST00000449281.1
ENST00000431948.6 [O75128-2]
L8E9S2
A0A0J9YWK3
ENST00000632460.1
ENST00000441453.5 [O75128-5]
ENST00000648294.1
ENST00000395540.6 [O75128-4]