Name | Number of supported studies | Average coverage | |
---|---|---|---|
oligodendrocyte | 16 studies | 62% ± 19% | |
oligodendrocyte precursor cell | 16 studies | 54% ± 24% | |
glutamatergic neuron | 11 studies | 48% ± 27% | |
ciliated cell | 9 studies | 35% ± 15% | |
type I pneumocyte | 8 studies | 39% ± 14% | |
astrocyte | 8 studies | 35% ± 13% | |
GABAergic neuron | 7 studies | 48% ± 11% | |
epithelial cell | 6 studies | 39% ± 20% | |
Mueller cell | 6 studies | 45% ± 15% | |
endothelial cell | 5 studies | 25% ± 11% | |
cardiac muscle cell | 5 studies | 31% ± 8% | |
goblet cell | 5 studies | 34% ± 31% | |
type II pneumocyte | 5 studies | 25% ± 5% | |
cholangiocyte | 4 studies | 55% ± 22% | |
neuron | 4 studies | 42% ± 15% | |
mesothelial cell | 4 studies | 33% ± 10% | |
retinal cone cell | 4 studies | 38% ± 19% | |
retinal rod cell | 4 studies | 42% ± 9% | |
club cell | 4 studies | 19% ± 3% | |
interneuron | 4 studies | 44% ± 24% | |
glial cell | 3 studies | 26% ± 7% | |
hepatocyte | 3 studies | 72% ± 22% | |
ependymal cell | 3 studies | 49% ± 10% | |
brush cell | 3 studies | 24% ± 6% | |
granule cell | 3 studies | 28% ± 2% | |
mucus secreting cell | 3 studies | 38% ± 12% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 9379.96 | 2640 / 2642 | 97% | 21.56 | 684 / 705 |
prostate | 94% | 2849.13 | 230 / 245 | 100% | 20.16 | 501 / 502 |
stomach | 98% | 2882.67 | 351 / 359 | 92% | 10.88 | 262 / 286 |
liver | 95% | 1854.96 | 214 / 226 | 87% | 8.07 | 355 / 406 |
intestine | 84% | 2161.93 | 816 / 966 | 94% | 10.70 | 493 / 527 |
kidney | 93% | 1947.35 | 83 / 89 | 76% | 9.28 | 685 / 901 |
pancreas | 87% | 1508.11 | 284 / 328 | 81% | 6.89 | 144 / 178 |
esophagus | 95% | 4495.80 | 1371 / 1445 | 65% | 9.35 | 119 / 183 |
thymus | 83% | 1489.66 | 540 / 653 | 75% | 5.63 | 451 / 605 |
lung | 88% | 2101.73 | 511 / 578 | 56% | 5.42 | 644 / 1155 |
breast | 44% | 1078.79 | 204 / 459 | 85% | 13.17 | 954 / 1118 |
muscle | 100% | 10302.61 | 803 / 803 | 0% | 0 | 0 / 0 |
skin | 72% | 4115.66 | 1302 / 1809 | 26% | 2.80 | 123 / 472 |
heart | 88% | 3356.59 | 761 / 861 | 0% | 0 | 0 / 0 |
ovary | 3% | 38.53 | 6 / 180 | 65% | 4.87 | 279 / 430 |
uterus | 5% | 86.82 | 8 / 170 | 40% | 4.08 | 182 / 459 |
bladder | 0% | 0 | 0 / 21 | 34% | 3.42 | 170 / 504 |
eye | 0% | 0 | 0 / 0 | 23% | 1.45 | 18 / 80 |
tonsil | 0% | 0 | 0 / 0 | 18% | 0.79 | 8 / 45 |
adrenal gland | 1% | 8.23 | 2 / 258 | 17% | 1.97 | 39 / 230 |
adipose | 14% | 217.64 | 173 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 3% | 0.98 | 1 / 29 |
blood vessel | 3% | 57.49 | 35 / 1335 | 0% | 0 | 0 / 0 |
peripheral blood | 0% | 1.18 | 1 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_1900029 | Biological process | positive regulation of ruffle assembly |
GO_0030041 | Biological process | actin filament polymerization |
GO_0048669 | Biological process | collateral sprouting in absence of injury |
GO_0001889 | Biological process | liver development |
GO_0001757 | Biological process | somite specification |
GO_0051639 | Biological process | actin filament network formation |
GO_1900006 | Biological process | positive regulation of dendrite development |
GO_0001843 | Biological process | neural tube closure |
GO_0048565 | Biological process | digestive tract development |
GO_0000578 | Biological process | embryonic axis specification |
GO_0030903 | Biological process | notochord development |
GO_0033504 | Biological process | floor plate development |
GO_0001726 | Cellular component | ruffle |
GO_0005886 | Cellular component | plasma membrane |
GO_0048471 | Cellular component | perinuclear region of cytoplasm |
GO_0016020 | Cellular component | membrane |
GO_0043025 | Cellular component | neuronal cell body |
GO_0005884 | Cellular component | actin filament |
GO_0030425 | Cellular component | dendrite |
GO_1990357 | Cellular component | terminal web |
GO_0044294 | Cellular component | dendritic growth cone |
GO_0005938 | Cellular component | cell cortex |
GO_0044295 | Cellular component | axonal growth cone |
GO_0030424 | Cellular component | axon |
GO_0003785 | Molecular function | actin monomer binding |
GO_0005515 | Molecular function | protein binding |
Gene name | COBL |
Protein name | Alternative protein COBL Cordon-bleu WH2 repeat protein Protein cordon-bleu |
Synonyms | KIAA0633 |
Description | FUNCTION: Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. . |
Accessions | O75128 ENST00000265136.12 [O75128-1] C9J9X1 ENST00000395542.6 [O75128-7] J3KR05 H7C1N2 ENST00000445054.5 A0A3B3IU00 ENST00000431948.5 ENST00000449281.1 ENST00000431948.6 [O75128-2] L8E9S2 A0A0J9YWK3 ENST00000632460.1 ENST00000441453.5 [O75128-5] ENST00000648294.1 ENST00000395540.6 [O75128-4] |