CLSTN3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
glutamatergic neuron	8 studies	39% ± 18%	Explore
GABAergic neuron	6 studies	38% ± 15%	Explore
endothelial cell	6 studies	31% ± 11%	Explore
neuron	5 studies	25% ± 8%	Explore
retinal bipolar neuron	4 studies	41% ± 4%	Explore
retinal cone cell	4 studies	23% ± 6%	Explore
interneuron	4 studies	43% ± 21%	Explore
CD16-negative, CD56-bright natural killer cell, human	3 studies	20% ± 1%	Explore
rod bipolar cell	3 studies	42% ± 7%	Explore
granule cell	3 studies	23% ± 4%	Explore
enteroendocrine cell	3 studies	22% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	6 studies	30% ± 15%	Explore
eye	4 studies	18% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	5657.44	459 / 459	98%	51.39	1100 / 1118
ovary	100%	7085.38	180 / 180	98%	54.65	420 / 430
thymus	100%	4208.35	651 / 653	98%	37.86	592 / 605
lung	100%	4753.69	576 / 578	96%	39.72	1114 / 1155
adrenal gland	100%	4132.57	257 / 258	96%	162.90	221 / 230
liver	100%	5533.74	226 / 226	96%	31.51	388 / 406
kidney	100%	5527.07	89 / 89	95%	74.62	853 / 901
uterus	100%	4463.67	170 / 170	94%	39.50	432 / 459
brain	92%	12712.87	2424 / 2642	99%	47.09	699 / 705
esophagus	97%	2618.90	1397 / 1445	92%	27.40	169 / 183
bladder	95%	3745.90	20 / 21	92%	36.89	463 / 504
prostate	100%	3814.44	244 / 245	84%	19.44	424 / 502
pancreas	85%	1751.74	279 / 328	98%	44.36	175 / 178
intestine	100%	3187.74	962 / 966	82%	18.15	432 / 527
stomach	86%	1979.78	307 / 359	85%	20.37	242 / 286
skin	97%	2875.35	1752 / 1809	67%	23.02	316 / 472
lymph node	0%	0	0 / 0	100%	34.97	29 / 29
spleen	100%	6695.12	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	15.01	1 / 1
adipose	100%	5232.02	1202 / 1204	0%	0	0 / 0
peripheral blood	97%	3888.87	898 / 929	0%	0	0 / 0
tonsil	0%	0	0 / 0	93%	24.22	42 / 45
blood vessel	88%	2181.81	1175 / 1335	0%	0	0 / 0
heart	58%	1112.71	499 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	33%	6.23	26 / 80
muscle	8%	112.97	62 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_1902474	Biological process	positive regulation of protein localization to synapse
GO_1905606	Biological process	regulation of presynapse assembly
GO_0001558	Biological process	regulation of cell growth
GO_0007156	Biological process	homophilic cell adhesion via plasma membrane adhesion molecules
GO_0051932	Biological process	synaptic transmission, GABAergic
GO_0050806	Biological process	positive regulation of synaptic transmission
GO_0007416	Biological process	synapse assembly
GO_0051965	Biological process	positive regulation of synapse assembly
GO_0035249	Biological process	synaptic transmission, glutamatergic
GO_0098978	Cellular component	glutamatergic synapse
GO_0098839	Cellular component	postsynaptic density membrane
GO_0005811	Cellular component	lipid droplet
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0032991	Cellular component	protein-containing complex
GO_0030425	Cellular component	dendrite
GO_0098982	Cellular component	GABA-ergic synapse
GO_0009986	Cellular component	cell surface
GO_0000139	Cellular component	Golgi membrane
GO_0045211	Cellular component	postsynaptic membrane
GO_0098632	Molecular function	cell-cell adhesion mediator activity
GO_0042043	Molecular function	neurexin family protein binding
GO_0005509	Molecular function	calcium ion binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	CLSTN3
Protein name	CLSTN3 protein Calsyntenin-3 (Alcadein-beta) (Alc-beta) Calsyntenin 3
Synonyms	KIAA0726 CS3
Description	FUNCTION: Postsynaptic adhesion molecule that binds to presynaptic neurexins to mediate both excitatory and inhibitory synapse formation . Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with both neurexin-alpha and neurexin-beta proteins at the presynaptic membrane . Regulates the balance between excitatory and inhibitory synapses by inhibiting formation of excitatory parallel-fiber synapses and promoting formation of inhibitory synapses in the same neuron (By similarity). May also be involved in ascorbate (vitamin C) uptake via its interaction with SLC23A2/SVCT2 . Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation (Probable). .; FUNCTION: [Isoform CLSTN3beta]: Adipose-specific isoform that plays a key role in adaptive thermogenesis. Facilitates the efficient use of stored triglyceride by promoting multilocular morphology of thermogenic adipocytes: acts by inhibiting the activity of CIDEA and CIDEC on lipid droplets, thereby preventing lipid droplet fusion and facilitating lipid utilization. May also participate in adaptive thermogenesis by promoting sympathetic innervation of thermogenic adipose tissue: acts by driving secretion of neurotrophic factor S100B from brown adipocytes, stimulating neurite outgrowth from sympathetic neurons. .
Accessions	ENST00000535452.5 Q9BQT9 F5H5C6 ENST00000266546.11 [Q9BQT9-1] ENST00000545663.5 ENST00000673375.1 [Q9BQT9-3] Q8IUW6 ENST00000541953.5 F5H5D7 F5H746 F5H172 ENST00000535313.2 [Q9BQT9-3] ENST00000672495.1 [Q9BQT9-1] ENST00000539982.5 ENST00000331148.5 ENST00000534830.5 F5H7C7 A0A3B3ISW0

CLSTN3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review