CLSTN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001558Biological processregulation of cell growth
GO_0007155Biological processcell adhesion
GO_0007156Biological processhomophilic cell adhesion via plasma membrane adhesion molecules
GO_0099003Biological processvesicle-mediated transport in synapse
GO_0050806Biological processpositive regulation of synaptic transmission
GO_0098969Biological processneurotransmitter receptor transport to postsynaptic membrane
GO_0051965Biological processpositive regulation of synapse assembly
GO_0090128Biological processregulation of synapse maturation
GO_0098978Cellular componentglutamatergic synapse
GO_0005576Cellular componentextracellular region
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0043005Cellular componentneuron projection
GO_0009986Cellular componentcell surface
GO_0000139Cellular componentGolgi membrane
GO_0014069Cellular componentpostsynaptic density
GO_0045211Cellular componentpostsynaptic membrane
GO_0098845Cellular componentpostsynaptic endosome
GO_0005634Cellular componentnucleus
GO_0001540Molecular functionamyloid-beta binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding
GO_0019894Molecular functionkinesin binding
GO_0042988Molecular functionX11-like protein binding

IV. Literature review

[source]
Gene nameCLSTN1
Protein nameCalsyntenin-1 (Alcadein-alpha) (Alc-alpha) (Alzheimer-related cadherin-like protein) (Non-classical cadherin XB31alpha) [Cleaved into: Soluble Alc-alpha (SAlc-alpha); CTF1-alpha (C-terminal fragment 1-alpha)]
Calsyntenin 1
SynonymsKIAA0911
CS1
DescriptionFUNCTION: Postsynaptic adhesion molecule that binds to presynaptic neurexins to mediate both excitatory and inhibitory synapse formation (By similarity). Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with neurexin-alpha at the presynaptic membrane (By similarity). Also functions as a cargo in axonal anterograde transport by acting as a molecular adapter that promotes KLC1 association with vesicles . Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation . .; FUNCTION: [Soluble Alc-alpha]: As intracellular fragment AlcICD, suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding . .; FUNCTION: [CTF1-alpha]: In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP . .

AccessionsENST00000361311.4 [O94985-2]
A0A3B3ITY6
ENST00000377298.9 [O94985-1]
Q5SR54
O94985
ENST00000435891.5
ENST00000650348.1