CLN8 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
plasmacytoid dendritic cell	19 studies	44% ± 18%	Explore
macrophage	10 studies	23% ± 5%	Explore
endothelial cell	7 studies	20% ± 4%	Explore
myeloid cell	6 studies	28% ± 9%	Explore
mononuclear phagocyte	4 studies	20% ± 3%	Explore
B cell	4 studies	17% ± 2%	Explore
microglial cell	4 studies	21% ± 6%	Explore
dendritic cell	3 studies	31% ± 18%	Explore
classical monocyte	3 studies	22% ± 4%	Explore
conventional dendritic cell	3 studies	40% ± 22%	Explore
epithelial cell	3 studies	33% ± 12%	Explore
leukocyte	3 studies	20% ± 5%	Explore
oligodendrocyte	3 studies	24% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	4 studies	23% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	2110.46	2642 / 2642	100%	15.88	705 / 705
kidney	100%	1648.63	89 / 89	99%	10.04	894 / 901
thymus	100%	1165.38	652 / 653	99%	8.18	599 / 605
prostate	100%	1202.90	244 / 245	99%	6.92	495 / 502
pancreas	100%	1305.21	328 / 328	98%	6.15	174 / 178
lung	100%	2594.90	577 / 578	97%	5.33	1115 / 1155
esophagus	100%	1264.52	1444 / 1445	96%	5.00	176 / 183
intestine	100%	1357.72	966 / 966	96%	4.50	504 / 527
uterus	100%	841.64	170 / 170	95%	5.18	435 / 459
breast	100%	1239.19	459 / 459	94%	5.20	1055 / 1118
skin	100%	2765.97	1809 / 1809	94%	6.57	444 / 472
bladder	100%	959.05	21 / 21	93%	4.43	470 / 504
stomach	100%	1540.87	359 / 359	90%	4.04	258 / 286
adrenal gland	100%	1393.40	258 / 258	88%	4.85	202 / 230
liver	100%	1284.66	226 / 226	64%	3.13	260 / 406
ovary	96%	676.11	173 / 180	54%	1.84	231 / 430
adipose	100%	1390.57	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	5.70	29 / 29
spleen	100%	2612.31	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	2.36	1 / 1
muscle	99%	875.59	797 / 803	0%	0	0 / 0
heart	99%	1072.37	850 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	5.43	44 / 45
peripheral blood	96%	1163.55	890 / 929	0%	0	0 / 0
blood vessel	95%	790.94	1272 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	76%	2.70	61 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007040	Biological process	lysosome organization
GO_0007601	Biological process	visual perception
GO_0007628	Biological process	adult walking behavior
GO_0060052	Biological process	neurofilament cytoskeleton organization
GO_0007006	Biological process	mitochondrial membrane organization
GO_0045494	Biological process	photoreceptor cell maintenance
GO_0008203	Biological process	cholesterol metabolic process
GO_0051935	Biological process	glutamate reuptake
GO_0050885	Biological process	neuromuscular process controlling balance
GO_0006672	Biological process	ceramide metabolic process
GO_0008306	Biological process	associative learning
GO_0021523	Biological process	somatic motor neuron differentiation
GO_0060041	Biological process	retina development in camera-type eye
GO_0097473	Biological process	retinal rod cell apoptotic process
GO_0008610	Biological process	lipid biosynthetic process
GO_0050884	Biological process	neuromuscular process controlling posture
GO_0046513	Biological process	ceramide biosynthetic process
GO_0045861	Biological process	negative regulation of proteolysis
GO_0030163	Biological process	protein catabolic process
GO_0006644	Biological process	phospholipid metabolic process
GO_0055088	Biological process	lipid homeostasis
GO_0008361	Biological process	regulation of cell size
GO_0050881	Biological process	musculoskeletal movement
GO_0035176	Biological process	social behavior
GO_0043524	Biological process	negative regulation of neuron apoptotic process
GO_0007399	Biological process	nervous system development
GO_0006869	Biological process	lipid transport
GO_0098793	Cellular component	presynapse
GO_0016020	Cellular component	membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0005739	Cellular component	mitochondrion
GO_0033116	Cellular component	endoplasmic reticulum-Golgi intermediate compartment membrane
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005793	Cellular component	endoplasmic reticulum-Golgi intermediate compartment
GO_0097001	Molecular function	ceramide binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	CLN8
Protein name	CLN8 transmembrane ER and ERGIC protein Protein CLN8 Ceroid-lipofuscinosis, neuronal 8 (Epilepsy, progressive with mental retardation)
Synonyms	C8orf61
Description	FUNCTION: Could play a role in cell proliferation during neuronal differentiation and in protection against cell death. .
Accessions	ENST00000632266.1 ENST00000519254.2 A0A0J9YWD2 ENST00000619400.2 ENST00000520991.3 A0A1B0GUR8 ENST00000635970.1 ENST00000636934.1 A0A1B0GU79 B9EGV9 A0A0J9YX19 ENST00000637083.1 A0A0J9YYK8 A0A0J9YXY6 ENST00000635751.1 ENST00000524258.2 Q9UBY8 ENST00000637594.1 ENST00000637156.1 ENST00000331222.6 ENST00000631624.1

CLN8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review