CLCN2 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of CLCN2 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
intestine	100%	1163.06	964 / 966	98%	8.96	516 / 527
brain	99%	729.44	2608 / 2642	99%	4.68	696 / 705
esophagus	99%	362.31	1429 / 1445	98%	6.07	180 / 183
ovary	100%	1074.35	180 / 180	97%	4.56	417 / 430
stomach	98%	364.68	352 / 359	97%	8.06	277 / 286
pancreas	99%	476.72	324 / 328	96%	3.34	171 / 178
breast	100%	372.56	458 / 459	95%	3.14	1061 / 1118
bladder	100%	407.19	21 / 21	94%	4.59	475 / 504
prostate	100%	513.19	244 / 245	93%	2.47	466 / 502
skin	98%	295.47	1771 / 1809	93%	3.52	440 / 472
uterus	100%	919.60	170 / 170	91%	3.27	418 / 459
thymus	100%	620.12	653 / 653	88%	1.76	532 / 605
kidney	100%	610.79	89 / 89	87%	2.45	785 / 901
lung	89%	265.84	514 / 578	93%	4.29	1077 / 1155
adrenal gland	100%	1014.29	258 / 258	66%	2.23	151 / 230
liver	82%	176.18	186 / 226	63%	1.69	256 / 406
ureter	0%	0	0 / 0	100%	2.37	1 / 1
spleen	99%	311.23	239 / 241	0%	0	0 / 0
blood vessel	99%	422.02	1322 / 1335	0%	0	0 / 0
adipose	98%	308.57	1175 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	87%	2.24	39 / 45
heart	71%	154.88	608 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	31%	0.49	25 / 80
lymph node	0%	0	0 / 0	31%	0.44	9 / 29
muscle	19%	32.48	154 / 803	0%	0	0 / 0
peripheral blood	16%	29.50	149 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0090425	Biological process	acinar cell differentiation
GO_0032347	Biological process	regulation of aldosterone biosynthetic process
GO_0030324	Biological process	lung development
GO_1902476	Biological process	chloride transmembrane transport
GO_0060041	Biological process	retina development in camera-type eye
GO_0060689	Biological process	cell differentiation involved in salivary gland development
GO_0006821	Biological process	chloride transport
GO_0048714	Biological process	positive regulation of oligodendrocyte differentiation
GO_0006911	Biological process	phagocytosis, engulfment
GO_0043204	Cellular component	perikaryon
GO_0034707	Cellular component	chloride channel complex
GO_0043209	Cellular component	myelin sheath
GO_0005886	Cellular component	plasma membrane
GO_0097450	Cellular component	astrocyte end-foot
GO_0016323	Cellular component	basolateral plasma membrane
GO_0030425	Cellular component	dendrite
GO_0005247	Molecular function	voltage-gated chloride channel activity

Gene name	CLCN2
Protein name	Chloride channel 2 isoform 1 Chloride channel 2 isoform 5 Chloride channel 2 isoform 3 Chloride channel protein 2 (ClC-2) Chloride voltage-gated channel 2 Chloride channel protein 2 Chloride channel 2 isoform 4 Chloride channel 2 isoform 2
Synonyms
Description	FUNCTION: Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. Involved in the regulation of aldosterone production. The opening of CLCN2 channels at hyperpolarized membrane potentials in the glomerulosa causes cell membrane depolarization, activation of voltage-gated Ca2+ channels and increased expression of aldosterone synthase, the rate-limiting enzyme for aldosterone biosynthesis . .
Accessions	A0A0S2Z3E4 H7C0Q8 ENST00000475279.2 ENST00000430397.5 ENST00000638134.1 ENST00000636419.1 ENST00000344937.11 [P51788-3] A0A1B0GTJ3 A0A1B0GUY6 ENST00000636180.1 A0A1B0GVU4 A0A1B0GWC8 A0A1B0GVL9 ENST00000637538.1 A0A172ZPS7 A0A1B0GV52 ENST00000265593.9 [P51788-1] A0A1B0GTY0 ENST00000636661.1 ENST00000636658.1 A0A0S2Z3J3 ENST00000457512.1 [P51788-5] A0A1B0GVW7 P51788 ENST00000434054.6 [P51788-4] A0A1B0GUZ8 A0A0S2Z364 ENST00000636241.1 A0A0S2Z368 ENST00000637909.1 A0A0S2Z3G7 ENST00000636492.1

CLCN2 report