CIART report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CIART at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CIART at tissue level.

III. Associated gene sets

GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0032922Biological processcircadian regulation of gene expression
GO_0045475Biological processlocomotor rhythm
GO_0016605Cellular componentPML body
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0070888Molecular functionE-box binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCIART
Protein nameC1orf51 protein
Chromosome 1 open reading frame 51
Chromosome 1 open reading frame 51 (Circadian associated repressor of transcription)
Circadian-associated transcriptional repressor (ChIP-derived repressor of network oscillator) (Chrono) (Computationally highlighted repressor of the network oscillator)
Circadian associated repressor of transcription
SynonymsRP4-790G17.5-004
hCG_1780614
C1orf51
RP4-790G17.5-003
RP4-790G17.5-005
DescriptionFUNCTION: Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Abrogates the interaction of BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-BMAL1 heterodimer, reducing histone acetylation of its target genes. Rhythmically binds the E-box elements (5'-CACGTG-3') on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to BMAL1. Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response (By similarity). .

AccessionsA0A1B0GX20
ENST00000290363.6 [Q8N365-1]
ENST00000369094.5
Q8WVX4
ENST00000417398.5
Q8N365
Q5TB13
ENST00000369095.5 [Q8N365-1]
Q5TB14
ENST00000447007.5
Q5TB12