CHSY1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045880Biological processpositive regulation of smoothened signaling pathway
GO_0030279Biological processnegative regulation of ossification
GO_0031667Biological processresponse to nutrient levels
GO_0009954Biological processproximal/distal pattern formation
GO_0060349Biological processbone morphogenesis
GO_0030206Biological processchondroitin sulfate biosynthetic process
GO_0051923Biological processsulfation
GO_0002063Biological processchondrocyte development
GO_0000139Cellular componentGolgi membrane
GO_0032580Cellular componentGolgi cisterna membrane
GO_0005576Cellular componentextracellular region
GO_0016020Cellular componentmembrane
GO_0050510Molecular functionN-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity
GO_0046872Molecular functionmetal ion binding
GO_0047238Molecular functionglucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity

IV. Literature review

[source]
Gene nameCHSY1
Protein nameAlternative protein CHSY1
Hexosyltransferase (EC 2.4.1.-)
Chondroitin sulfate synthase 1 (EC 2.4.1.175) (EC 2.4.1.226) (Chondroitin glucuronyltransferase 1) (Chondroitin synthase 1) (ChSy-1) (Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase 1) (N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 1) (N-acetylgalactosaminyltransferase 1)
SynonymsCHSY
UNQ756/PRO1487
CSS1
KIAA0990
DescriptionFUNCTION: Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Involved in the negative control of osteogenesis likely through the modulation of NOTCH signaling. .

AccessionsA0A2R8Y7B7
L8E844
ENST00000254190.4
ENST00000543813.2
Q86X52