CHST15 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030206Biological processchondroitin sulfate biosynthetic process
GO_0019319Biological processhexose biosynthetic process
GO_0000139Cellular componentGolgi membrane
GO_0016020Cellular componentmembrane
GO_0050656Molecular function3'-phosphoadenosine 5'-phosphosulfate binding
GO_0050659Molecular functionN-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCHST15
Protein nameAlternative protein CHST15
Carbohydrate sulfotransferase 15 (EC 2.8.2.33) (B-cell RAG-associated gene protein) (hBRAG) (N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase) (GalNAc4S-6ST)
Carbohydrate sulfotransferase 15
SynonymsBRAG
GALNAC4S6ST
KIAA0598
DescriptionFUNCTION: Sulfotransferase that transfers sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to the C-6 hydroxyl group of the GalNAc 4-sulfate residue of chondroitin sulfate A and forms chondroitin sulfate E containing GlcA-GalNAc(4,6-SO(4)) repeating units. It also transfers sulfate to a unique non-reducing terminal sequence, GalNAc(4SO4)-GlcA(2SO4)-GalNAc(6SO4), to yield a highly sulfated structure similar to the structure found in thrombomodulin chondroitin sulfate. May also act as a B-cell receptor involved in BCR ligation-mediated early activation that mediate regulatory signals key to B-cell development and/or regulation of B-cell-specific RAG expression; however such results are unclear in vivo. .

AccessionsL8ECG4
ENST00000346248.7 [Q7LFX5-1]
L8EAU1
Q7LFX5
A0A0D9SFZ3
ENST00000462406.1
ENST00000435907.6 [Q7LFX5-1]
ENST00000628426.1 [Q7LFX5-2]