Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 11 studies | 54% ± 20% | |
| GABAergic neuron | 8 studies | 43% ± 19% | |
| neuron | 6 studies | 25% ± 12% | |
| amacrine cell | 6 studies | 39% ± 9% | |
| interneuron | 5 studies | 48% ± 25% | |
| retina horizontal cell | 5 studies | 33% ± 6% | |
| GABAergic interneuron | 3 studies | 44% ± 9% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 11 studies | 36% ± 19% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 90% | 10230.87 | 2369 / 2642 | 83% | 12.02 | 586 / 705 |
| adrenal gland | 14% | 388.54 | 36 / 258 | 62% | 10.50 | 143 / 230 |
| esophagus | 51% | 1257.97 | 732 / 1445 | 13% | 0.50 | 24 / 183 |
| blood vessel | 28% | 442.22 | 370 / 1335 | 0% | 0 | 0 / 0 |
| prostate | 7% | 91.31 | 17 / 245 | 20% | 0.43 | 99 / 502 |
| stomach | 9% | 128.38 | 34 / 359 | 7% | 0.22 | 20 / 286 |
| pancreas | 1% | 7.03 | 2 / 328 | 15% | 0.97 | 26 / 178 |
| thymus | 0% | 3.06 | 1 / 653 | 13% | 0.40 | 78 / 605 |
| kidney | 2% | 42.55 | 2 / 89 | 9% | 0.58 | 84 / 901 |
| bladder | 10% | 105.19 | 2 / 21 | 2% | 0.05 | 8 / 504 |
| eye | 0% | 0 | 0 / 0 | 10% | 0.33 | 8 / 80 |
| intestine | 4% | 40.02 | 35 / 966 | 3% | 0.08 | 16 / 527 |
| uterus | 1% | 6.24 | 1 / 170 | 6% | 0.19 | 26 / 459 |
| lung | 0% | 0 | 0 / 578 | 4% | 0.13 | 50 / 1155 |
| breast | 0% | 0 | 0 / 459 | 4% | 0.16 | 45 / 1118 |
| ovary | 1% | 10.38 | 2 / 180 | 1% | 0.05 | 6 / 430 |
| skin | 0% | 6.02 | 6 / 1809 | 1% | 0.06 | 4 / 472 |
| adipose | 1% | 10.04 | 9 / 1204 | 0% | 0 | 0 / 0 |
| liver | 0% | 0 | 0 / 226 | 1% | 0.01 | 3 / 406 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| heart | 0% | 0 | 0 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| muscle | 0% | 0 | 0 / 803 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_1901798 | Biological process | positive regulation of signal transduction by p53 class mediator |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0006338 | Biological process | chromatin remodeling |
| GO_0035092 | Biological process | sperm DNA condensation |
| GO_0021895 | Biological process | cerebral cortex neuron differentiation |
| GO_0016020 | Cellular component | membrane |
| GO_0000792 | Cellular component | heterochromatin |
| GO_0016607 | Cellular component | nuclear speck |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0016581 | Cellular component | NuRD complex |
| GO_0000785 | Cellular component | chromatin |
| GO_0005634 | Cellular component | nucleus |
| GO_0003677 | Molecular function | DNA binding |
| GO_0004386 | Molecular function | helicase activity |
| GO_0042393 | Molecular function | histone binding |
| GO_0003682 | Molecular function | chromatin binding |
| GO_0061628 | Molecular function | H3K27me3 modified histone binding |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0005524 | Molecular function | ATP binding |
| GO_0140658 | Molecular function | ATP-dependent chromatin remodeler activity |
| GO_0016887 | Molecular function | ATP hydrolysis activity |
| Gene name | CHD5 |
| Protein name | Chromodomain helicase DNA binding protein 5 Chromodomain-helicase-DNA-binding protein 5 (CHD-5) (EC 3.6.4.12) (ATP-dependent helicase CHD5) DNA helicase (EC 3.6.4.12) |
| Synonyms | KIAA0444 |
| Description | FUNCTION: Chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. May specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. Regulates the expression of genes involved in cell proliferation and differentiation. Downstream activated genes may include CDKN2A that positively regulates the p53/TP53 pathway, which in turn, prevents cell proliferation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. . |
| Accessions | ENST00000491020.1 Q8TDI0 F6T542 ENST00000377999.5 ENST00000462991.5 ENST00000496404.1 ENST00000262450.8 F2Z2R5 K7EMC0 K7ESA5 K7EMY3 ENST00000475121.1 |
