Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| smooth muscle cell | 19 studies | 30% ± 12% | |
| pericyte | 14 studies | 21% ± 6% | |
| endothelial cell of lymphatic vessel | 10 studies | 21% ± 5% | |
| fibroblast | 9 studies | 28% ± 9% | |
| type I pneumocyte | 7 studies | 26% ± 11% | |
| oligodendrocyte | 7 studies | 35% ± 10% | |
| myofibroblast cell | 7 studies | 25% ± 5% | |
| endothelial cell | 5 studies | 27% ± 6% | |
| cardiac muscle cell | 5 studies | 21% ± 6% | |
| connective tissue cell | 5 studies | 30% ± 13% | |
| retinal ganglion cell | 4 studies | 69% ± 27% | |
| neuron | 4 studies | 32% ± 14% | |
| retinal bipolar neuron | 3 studies | 28% ± 9% | |
| epithelial cell | 3 studies | 40% ± 17% | |
| retina horizontal cell | 3 studies | 24% ± 7% | |
| retinal rod cell | 3 studies | 22% ± 3% | |
| Mueller cell | 3 studies | 32% ± 5% | |
| muscle cell | 3 studies | 29% ± 17% | |
| luminal cell of prostate epithelium | 3 studies | 18% ± 1% | |
| GABAergic neuron | 3 studies | 24% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| adrenal gland | 100% | 6932.54 | 257 / 258 | 99% | 38.84 | 228 / 230 |
| brain | 99% | 5072.76 | 2614 / 2642 | 100% | 62.20 | 703 / 705 |
| ovary | 99% | 3805.69 | 178 / 180 | 100% | 22.61 | 429 / 430 |
| liver | 98% | 3670.20 | 222 / 226 | 99% | 35.60 | 400 / 406 |
| prostate | 93% | 5483.46 | 228 / 245 | 100% | 34.69 | 501 / 502 |
| thymus | 93% | 2468.82 | 605 / 653 | 98% | 22.23 | 594 / 605 |
| uterus | 99% | 8123.88 | 168 / 170 | 88% | 24.01 | 406 / 459 |
| lung | 96% | 3161.17 | 552 / 578 | 92% | 18.18 | 1058 / 1155 |
| breast | 98% | 3543.90 | 451 / 459 | 87% | 11.82 | 977 / 1118 |
| bladder | 100% | 8645.62 | 21 / 21 | 64% | 10.48 | 322 / 504 |
| kidney | 66% | 1611.31 | 59 / 89 | 97% | 26.70 | 870 / 901 |
| esophagus | 75% | 7530.53 | 1088 / 1445 | 87% | 17.38 | 160 / 183 |
| skin | 38% | 2568.82 | 692 / 1809 | 95% | 24.38 | 449 / 472 |
| intestine | 82% | 8845.84 | 789 / 966 | 51% | 7.28 | 270 / 527 |
| stomach | 56% | 4247.78 | 202 / 359 | 67% | 14.21 | 191 / 286 |
| muscle | 100% | 30520.27 | 803 / 803 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 10621.57 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 99% | 4309.19 | 1197 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 99% | 19.58 | 79 / 80 |
| heart | 94% | 13404.83 | 813 / 861 | 0% | 0 | 0 / 0 |
| pancreas | 4% | 78.50 | 12 / 328 | 85% | 13.10 | 152 / 178 |
| tonsil | 0% | 0 | 0 / 0 | 82% | 10.34 | 37 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 41% | 3.65 | 12 / 29 |
| spleen | 33% | 639.56 | 79 / 241 | 0% | 0 | 0 / 0 |
| peripheral blood | 2% | 40.52 | 21 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0051014 | Biological process | actin filament severing |
| GO_0045214 | Biological process | sarcomere organization |
| GO_0030836 | Biological process | positive regulation of actin filament depolymerization |
| GO_0007519 | Biological process | skeletal muscle tissue development |
| GO_0046716 | Biological process | muscle cell cellular homeostasis |
| GO_0030043 | Biological process | actin filament fragmentation |
| GO_0030042 | Biological process | actin filament depolymerization |
| GO_0016363 | Cellular component | nuclear matrix |
| GO_0005615 | Cellular component | extracellular space |
| GO_0015629 | Cellular component | actin cytoskeleton |
| GO_0031674 | Cellular component | I band |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0030018 | Cellular component | Z disc |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0051015 | Molecular function | actin filament binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | CFL2 |
| Protein name | Cofilin-2 Cofilin 2 Cofilin-2 (Cofilin, muscle isoform) |
| Synonyms | hCG_21174 |
| Description | FUNCTION: Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. Its F-actin depolymerization activity is regulated by association with CSPR3 . It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere (By similarity). . |
| Accessions | Q549N0 ENST00000422678.2 ENST00000672517.1 [Q9Y281-1] ENST00000556161.1 [Q9Y281-3] ENST00000341223.8 [Q9Y281-1] Q9Y281 G3V2U0 ENST00000555765.5 [Q9Y281-3] ENST00000672163.1 [Q9Y281-1] ENST00000673315.1 [Q9Y281-3] ENST00000554470.5 F8WDN3 ENST00000298159.11 [Q9Y281-1] |