CFL2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051014Biological processactin filament severing
GO_0045214Biological processsarcomere organization
GO_0030836Biological processpositive regulation of actin filament depolymerization
GO_0007519Biological processskeletal muscle tissue development
GO_0046716Biological processmuscle cell cellular homeostasis
GO_0030043Biological processactin filament fragmentation
GO_0030042Biological processactin filament depolymerization
GO_0016363Cellular componentnuclear matrix
GO_0005615Cellular componentextracellular space
GO_0015629Cellular componentactin cytoskeleton
GO_0031674Cellular componentI band
GO_0070062Cellular componentextracellular exosome
GO_0030018Cellular componentZ disc
GO_0005737Cellular componentcytoplasm
GO_0051015Molecular functionactin filament binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCFL2
Protein nameCofilin-2
Cofilin 2
Cofilin-2 (Cofilin, muscle isoform)
SynonymshCG_21174
DescriptionFUNCTION: Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. Its F-actin depolymerization activity is regulated by association with CSPR3 . It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere (By similarity). .

AccessionsQ549N0
ENST00000422678.2
ENST00000672517.1 [Q9Y281-1]
ENST00000556161.1 [Q9Y281-3]
ENST00000341223.8 [Q9Y281-1]
Q9Y281
G3V2U0
ENST00000555765.5 [Q9Y281-3]
ENST00000672163.1 [Q9Y281-1]
ENST00000673315.1 [Q9Y281-3]
ENST00000554470.5
F8WDN3
ENST00000298159.11 [Q9Y281-1]