CERS3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CERS3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CERS3 at tissue level.

III. Associated gene sets

GO_0030148Biological processsphingolipid biosynthetic process
GO_0030216Biological processkeratinocyte differentiation
GO_0008544Biological processepidermis development
GO_0070268Biological processcornification
GO_0046513Biological processceramide biosynthetic process
GO_0005783Cellular componentendoplasmic reticulum
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0003677Molecular functionDNA binding
GO_0050291Molecular functionsphingosine N-acyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCERS3
Protein nameCeramide synthase 3 (CerS3) (Dihydroceramide synthase 3) (LAG1 longevity assurance homolog 3) (Sphingosine N-acyltransferase CERS3) (EC 2.3.1.24) (Ultra-long-chain ceramide synthase CERS3) (EC 2.3.1.298) (Very-long-chain ceramide synthase CERS3) (EC 2.3.1.297)
Ceramide synthase 3
SynonymsLASS3
DescriptionFUNCTION: Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward very- and ultra-long-chain fatty acyl-CoA (chain length greater than C22) . N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively . It is crucial for the synthesis of ultra-long-chain ceramides in the epidermis, to maintain epidermal lipid homeostasis and terminal differentiation . .

AccessionsQ8IU89
ENST00000284382.8
ENST00000538112.6
H0YMG6
ENST00000394113.5
ENST00000679737.1
ENST00000558884.6
ENST00000559639.1
H0YN05