CENPW report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051301Biological processcell division
GO_0000278Biological processmitotic cell cycle
GO_0051276Biological processchromosome organization
GO_0034080Biological processCENP-A containing chromatin assembly
GO_0007059Biological processchromosome segregation
GO_0051382Biological processkinetochore assembly
GO_0000775Cellular componentchromosome, centromeric region
GO_0016363Cellular componentnuclear matrix
GO_0005730Cellular componentnucleolus
GO_0000776Cellular componentkinetochore
GO_0005634Cellular componentnucleus
GO_0005654Cellular componentnucleoplasm
GO_0000939Cellular componentinner kinetochore
GO_0046982Molecular functionprotein heterodimerization activity
GO_0003677Molecular functionDNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCENPW
Protein nameCentromere protein W
Centromere protein W (CENP-W) (Cancer-up-regulated gene 2 protein)
SynonymsC6orf173
CUG2
DescriptionFUNCTION: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPW has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis. .

AccessionsQ5EE01
ENST00000368328.5 [Q5EE01-1]
ENST00000368326.5
ENST00000368325.5 [Q5EE01-2]
A0A0A0MRK5