CENPS report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CENPS at tissue level.

III. Associated gene sets

GO_0006281Biological processDNA repair
GO_0036297Biological processinterstrand cross-link repair
GO_0007059Biological processchromosome segregation
GO_0006974Biological processDNA damage response
GO_0051301Biological processcell division
GO_0031297Biological processreplication fork processing
GO_0000712Biological processresolution of meiotic recombination intermediates
GO_0031398Biological processpositive regulation of protein ubiquitination
GO_0000939Cellular componentinner kinetochore
GO_0005654Cellular componentnucleoplasm
GO_0043240Cellular componentFanconi anaemia nuclear complex
GO_0005829Cellular componentcytosol
GO_0071821Cellular componentFANCM-MHF complex
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0003682Molecular functionchromatin binding
GO_0003690Molecular functiondouble-stranded DNA binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCENPS
Protein nameCentromere protein S (CENP-S) (Apoptosis-inducing TAF9-like domain-containing protein 1) (FANCM-associated histone fold protein 1) (FANCM-interacting histone fold protein 1) (Fanconi anemia-associated polypeptide of 16 kDa)
Centromere protein S
CENPS-CORT readthrough (Centromere protein S)
SynonymsCENPS-CORT
APITD1
MHF1
FAAP16
DescriptionFUNCTION: DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage . In complex with CENPX (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM . In complex with CENPX and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks . In complex with CENPT, CENPW and CENPX (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression . As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure . DNA-binding function is fulfilled in the presence of CENPX, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded. Does not bind DNA on its own . .

AccessionsENST00000309048.8 [Q8N2Z9-1]
ENST00000465026.1
ENST00000462462.1
Q8N2Z9
A0A0U1RQL5
K7ESB0
ENST00000477755.1