CENPJ report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1905515Biological processnon-motile cilium assembly
GO_0060271Biological processcilium assembly
GO_0007224Biological processsmoothened signaling pathway
GO_1903724Biological processpositive regulation of centriole elongation
GO_0046601Biological processpositive regulation of centriole replication
GO_0044458Biological processmotile cilium assembly
GO_0051301Biological processcell division
GO_0007020Biological processmicrotubule nucleation
GO_0046599Biological processregulation of centriole replication
GO_0030954Biological processastral microtubule nucleation
GO_1905832Biological processpositive regulation of spindle assembly
GO_1904951Biological processpositive regulation of establishment of protein localization
GO_1900087Biological processpositive regulation of G1/S transition of mitotic cell cycle
GO_0061511Biological processcentriole elongation
GO_0046785Biological processmicrotubule polymerization
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_1902857Biological processpositive regulation of non-motile cilium assembly
GO_0060236Biological processregulation of mitotic spindle organization
GO_0046427Biological processpositive regulation of receptor signaling pathway via JAK-STAT
GO_0007099Biological processcentriole replication
GO_0005874Cellular componentmicrotubule
GO_0005813Cellular componentcentrosome
GO_0005814Cellular componentcentriole
GO_0008275Cellular componentgamma-tubulin small complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0120099Cellular componentprocentriole replication complex
GO_0036064Cellular componentciliary basal body
GO_0043015Molecular functiongamma-tubulin binding
GO_0019904Molecular functionprotein domain specific binding
GO_0015631Molecular functiontubulin binding
GO_0019901Molecular functionprotein kinase binding
GO_0042802Molecular functionidentical protein binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCENPJ
Protein nameCentromere protein J
CENPJ protein
Centromere protein J (CENP-J) (Centrosomal P4.1-associated protein) (LAG-3-associated protein) (LYST-interacting protein 1)
SynonymsLAP
CPAP
LIP1
DescriptionFUNCTION: Plays an important role in cell division and centrosome function by participating in centriole duplication . Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as a microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles . Required for centriole elongation and for STIL-mediated centriole amplification . Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner . May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release . .

AccessionsQ2KHM5
ENST00000616936.4 [Q9HC77-2]
H0Y5L8
Q9HC77
F6VUX8
ENST00000381884.9 [Q9HC77-1]
ENST00000418179.1
Q569I1
ENST00000545981.6