CENATAC report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000398Biological processmRNA splicing, via spliceosome
GO_0010826Biological processnegative regulation of centrosome duplication
GO_0042176Biological processregulation of protein catabolic process
GO_0051304Biological processchromosome separation
GO_0005813Cellular componentcentrosome
GO_0005737Cellular componentcytoplasm
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCENATAC
Protein nameCentrosomal AT-AC splicing factor (Coiled-coil domain-containing protein 84)
SynonymsCCDC84
DLNB14
DescriptionFUNCTION: Component of the minor spliceosome that promotes splicing of a specific, rare minor intron subtype . Negative regulator of centrosome duplication . Constrains centriole number by modulating the degradation of the centrosome-duplication-associated protein SASS6 in an acetylation-dependent manner. SIRT1 deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly. The CENATAC acetylation level is restored in mitosis by NAT10, promoting SASS6 proteasome degradation by facilitating SASS6 binding to APC/C E3 ubiquitin-protein ligase complex/FZR1 . .

AccessionsENST00000626123
ENST00000625528.3
ENST00000532132.5
ENST00000334418.6
Q86UT8
E9PPT8
E9PJ16
ENST00000526463.5
ENST00000626384