CDS2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0140042Biological processlipid droplet formation
GO_0006655Biological processphosphatidylglycerol biosynthetic process
GO_0016024Biological processCDP-diacylglycerol biosynthetic process
GO_0005743Cellular componentmitochondrial inner membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0004605Molecular functionphosphatidate cytidylyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCDS2
Protein namePhosphatidate cytidylyltransferase 2 (EC 2.7.7.41) (CDP-DAG synthase 2) (CDP-DG synthase 2) (CDP-diacylglycerol synthase 2) (CDS 2) (CDP-diglyceride pyrophosphorylase 2) (CDP-diglyceride synthase 2) (CTP:phosphatidate cytidylyltransferase 2)
Synonyms
DescriptionFUNCTION: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol . Exhibits specificity for the nature of the acyl chains at the sn-1 and sn-2 positions in the substrate, PA and the preferred acyl chain composition is 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid . Plays an important role in regulating the growth and maturation of lipid droplets which are storage organelles at the center of lipid and energy homeostasis . .

AccessionsENST00000450570.1 [O95674-2]
O95674
ENST00000460006.6 [O95674-1]