CDKN1C report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030511Biological processpositive regulation of transforming growth factor beta receptor signaling pathway
GO_0033673Biological processnegative regulation of kinase activity
GO_0045930Biological processnegative regulation of mitotic cell cycle
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0045736Biological processnegative regulation of cyclin-dependent protein serine/threonine kinase activity
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0050680Biological processnegative regulation of epithelial cell proliferation
GO_1904030Biological processnegative regulation of cyclin-dependent protein kinase activity
GO_0042326Biological processnegative regulation of phosphorylation
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0044877Molecular functionprotein-containing complex binding
GO_0004860Molecular functionprotein kinase inhibitor activity
GO_0140678Molecular functionmolecular function inhibitor activity
GO_0004861Molecular functioncyclin-dependent protein serine/threonine kinase inhibitor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCDKN1C
Protein nameCyclin dependent kinase inhibitor 1C
Cyclin-dependent kinase inhibitor 1C transcript variant 3
Cyclin-dependent kinase inhibitor 1C (Cyclin-dependent kinase inhibitor p57) (p57Kip2)
Cyclin-dependent kinase inhibitor 1C
SynonymsKIP2
DescriptionFUNCTION: Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.

AccessionsENST00000633020.1
ENST00000313407.10
P49918
A0A0G2JPX0
ENST00000380725.2
ENST00000440480.8 [P49918-2]
ENST00000616138.2
ENST00000631604.1
A6NK88
B2D1N3
ENST00000414822.8 [P49918-1]
A0A2R8YFP9
A0A0G2JH30
ENST00000647251.1
ENST00000430149.3 [P49918-1]