CD68 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071222Biological processcellular response to lipopolysaccharide
GO_0002605Biological processnegative regulation of dendritic cell antigen processing and presentation
GO_0031669Biological processcellular response to nutrient levels
GO_0140052Biological processcellular response to oxidised low-density lipoprotein particle stimulus
GO_0002437Biological processinflammatory response to antigenic stimulus
GO_0072594Biological processestablishment of protein localization to organelle
GO_0005764Cellular componentlysosome
GO_0035577Cellular componentazurophil granule membrane
GO_0031902Cellular componentlate endosome membrane
GO_0005886Cellular componentplasma membrane
GO_0005765Cellular componentlysosomal membrane
GO_0016020Cellular componentmembrane
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCD68
Protein nameMacrosialin (Gp110) (CD antigen CD68)
CD68 molecule
Synonyms
DescriptionFUNCTION: Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.

AccessionsJ3KT24
ENST00000250092.11 [P34810-1]
J3KRX0
P34810
ENST00000584180.1
ENST00000380498.10 [P34810-3]
ENST00000584502.1