CCDC93 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0015031Biological processprotein transport
GO_0032456Biological processendocytic recycling
GO_0006893Biological processGolgi to plasma membrane transport
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005769Cellular componentearly endosome
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCCDC93
Protein nameCoiled-coil domain-containing protein 93
Synonyms
DescriptionFUNCTION: Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels. The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1 . Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes and is dependent on its interaction with WASHC2C . .; FUNCTION: (Microbial infection) The CCC complex, in collaboration with the heterotrimeric retriever complex, mediates the exit of human papillomavirus to the cell surface. .

AccessionsENST00000437999.5
Q567U6
ENST00000319432.9
H7C050
F8W9X7
ENST00000376300.7