CC2D1A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0002087Biological processregulation of respiratory gaseous exchange by nervous system process
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0150023Biological processapical dendrite arborization
GO_1905381Biological processnegative regulation of snRNA transcription by RNA polymerase II
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0007032Biological processendosome organization
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005813Cellular componentcentrosome
GO_0070062Cellular componentextracellular exosome
GO_0001650Cellular componentfibrillar center
GO_0005829Cellular componentcytosol
GO_0010008Cellular componentendosome membrane
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0045296Molecular functioncadherin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCC2D1A
Protein nameCC2D1A protein
Coiled-coil and C2 domain-containing protein 1A (Akt kinase-interacting protein 1) (Five prime repressor element under dual repression-binding protein 1) (FRE under dual repression-binding protein 1) (Freud-1) (Putative NF-kappa-B-activating protein 023N)
Coiled-coil and C2 domain containing 1A
SynonymsLGD2
AKI1
DescriptionFUNCTION: Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (By similarity). Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis. .

AccessionsENST00000680977.1
ENST00000587508.1
Q6P1N0
Q24K25
A0A7P0Z4M5
K7EJY5
ENST00000672017.1 [Q6P1N0-1]
ENST00000318003.11 [Q6P1N0-1]
ENST00000586955.5
ENST00000672339.1 [Q6P1N0-2]
ENST00000589606.5 [Q6P1N0-2]
K7EMP1