CASQ1 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of CASQ1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	82%	418.70	2169 / 2642	99%	26.44	700 / 705
prostate	85%	428.09	208 / 245	60%	5.86	301 / 502
bladder	81%	502.90	17 / 21	47%	9.85	239 / 504
muscle	100%	72863.12	803 / 803	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	2.68	1 / 1
heart	96%	1647.77	828 / 861	0%	0	0 / 0
breast	32%	103.27	147 / 459	51%	2.89	570 / 1118
blood vessel	81%	259.42	1075 / 1335	0%	0	0 / 0
esophagus	62%	285.38	894 / 1445	9%	0.18	17 / 183
intestine	64%	184.84	619 / 966	5%	0.12	28 / 527
lymph node	0%	0	0 / 0	69%	2.80	20 / 29
ovary	8%	12.23	14 / 180	43%	1.52	183 / 430
spleen	49%	87.44	119 / 241	0%	0	0 / 0
uterus	25%	52.86	42 / 170	24%	4.99	112 / 459
stomach	17%	33.53	62 / 359	11%	0.33	31 / 286
skin	13%	30.55	231 / 1809	13%	0.42	59 / 472
lung	12%	20.94	72 / 578	12%	0.48	139 / 1155
pancreas	1%	1.16	3 / 328	19%	1.17	34 / 178
tonsil	0%	0	0 / 0	20%	3.83	9 / 45
adipose	19%	35.38	223 / 1204	0%	0	0 / 0
adrenal gland	4%	10.59	10 / 258	9%	0.17	20 / 230
peripheral blood	9%	59.09	82 / 929	0%	0	0 / 0
thymus	4%	27.47	29 / 653	4%	0.35	26 / 605
kidney	0%	0	0 / 89	8%	0.19	70 / 901
liver	1%	1.99	3 / 226	5%	0.14	19 / 406
eye	0%	0	0 / 0	3%	0.14	2 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0009408	Biological process	response to heat
GO_0007519	Biological process	skeletal muscle tissue development
GO_0007029	Biological process	endoplasmic reticulum organization
GO_0014894	Biological process	response to denervation involved in regulation of muscle adaptation
GO_1901341	Biological process	positive regulation of store-operated calcium channel activity
GO_0051258	Biological process	protein polymerization
GO_0051281	Biological process	positive regulation of release of sequestered calcium ion into cytosol
GO_0045214	Biological process	sarcomere organization
GO_0014809	Biological process	regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
GO_2001256	Biological process	regulation of store-operated calcium entry
GO_0030018	Cellular component	Z disc
GO_0005739	Cellular component	mitochondrion
GO_0005790	Cellular component	smooth endoplasmic reticulum
GO_0033018	Cellular component	sarcoplasmic reticulum lumen
GO_0014804	Cellular component	terminal cisterna lumen
GO_0030315	Cellular component	T-tubule
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005759	Cellular component	mitochondrial matrix
GO_0016529	Cellular component	sarcoplasmic reticulum
GO_0033017	Cellular component	sarcoplasmic reticulum membrane
GO_0042802	Molecular function	identical protein binding
GO_0005509	Molecular function	calcium ion binding
GO_0005515	Molecular function	protein binding

Gene name	CASQ1
Protein name	Calsequestrin Calsequestrin-1 (Calmitine) (Calsequestrin, skeletal muscle isoform)
Synonyms	CASQ
Description	FUNCTION: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle . Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions . Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction. Negatively regulates store-operated Ca(2+) entry (SOCE) activity . . FUNCTION: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. .
Accessions	P31415 C9JAC8 ENST00000368078.8 ENST00000467691.1

CASQ1 report