Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 13 studies | 25% ± 9% | |
glutamatergic neuron | 6 studies | 35% ± 19% | |
oligodendrocyte | 6 studies | 22% ± 5% | |
ciliated cell | 5 studies | 21% ± 7% | |
astrocyte | 5 studies | 26% ± 7% | |
classical monocyte | 4 studies | 19% ± 2% | |
neuron | 4 studies | 28% ± 10% | |
pericyte | 4 studies | 20% ± 4% | |
smooth muscle cell | 4 studies | 17% ± 1% | |
epithelial cell | 4 studies | 35% ± 7% | |
fibroblast | 4 studies | 20% ± 6% | |
GABAergic neuron | 4 studies | 38% ± 14% | |
oligodendrocyte precursor cell | 4 studies | 22% ± 6% | |
interneuron | 4 studies | 34% ± 20% | |
microglial cell | 3 studies | 19% ± 1% | |
basal cell | 3 studies | 23% ± 5% | |
myofibroblast cell | 3 studies | 17% ± 1% | |
abnormal cell | 3 studies | 22% ± 6% | |
macrophage | 3 studies | 18% ± 4% | |
goblet cell | 3 studies | 17% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 9221.58 | 1445 / 1445 | 100% | 73.84 | 183 / 183 |
prostate | 100% | 9476.51 | 245 / 245 | 100% | 67.64 | 502 / 502 |
brain | 100% | 9182.81 | 2641 / 2642 | 100% | 103.49 | 705 / 705 |
lung | 100% | 9670.29 | 578 / 578 | 100% | 55.40 | 1154 / 1155 |
thymus | 100% | 10348.67 | 653 / 653 | 100% | 64.59 | 604 / 605 |
intestine | 100% | 10053.96 | 966 / 966 | 100% | 53.06 | 526 / 527 |
stomach | 100% | 7345.17 | 359 / 359 | 100% | 58.83 | 285 / 286 |
breast | 100% | 10131.25 | 459 / 459 | 100% | 94.98 | 1114 / 1118 |
bladder | 100% | 11669.62 | 21 / 21 | 100% | 50.07 | 502 / 504 |
skin | 100% | 8489.88 | 1809 / 1809 | 100% | 60.67 | 470 / 472 |
uterus | 100% | 12547.86 | 170 / 170 | 100% | 53.73 | 457 / 459 |
pancreas | 100% | 5280.34 | 328 / 328 | 99% | 44.13 | 177 / 178 |
ovary | 100% | 10885.49 | 180 / 180 | 99% | 50.59 | 427 / 430 |
kidney | 100% | 5989.25 | 89 / 89 | 98% | 43.39 | 882 / 901 |
adrenal gland | 100% | 6476.79 | 258 / 258 | 93% | 35.45 | 215 / 230 |
liver | 100% | 2966.15 | 226 / 226 | 93% | 28.42 | 378 / 406 |
adipose | 100% | 9763.85 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 12204.38 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 46.29 | 29 / 29 |
peripheral blood | 100% | 11179.88 | 929 / 929 | 0% | 0 | 0 / 0 |
spleen | 100% | 8644.97 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 48.57 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 19.55 | 1 / 1 |
muscle | 100% | 7007.68 | 802 / 803 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 99% | 55.78 | 79 / 80 |
heart | 99% | 4191.64 | 850 / 861 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0000184 | Biological process | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
GO_0006417 | Biological process | regulation of translation |
GO_0000398 | Biological process | mRNA splicing, via spliceosome |
GO_0006406 | Biological process | mRNA export from nucleus |
GO_2000622 | Biological process | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
GO_0008298 | Biological process | intracellular mRNA localization |
GO_0048471 | Cellular component | perinuclear region of cytoplasm |
GO_0016607 | Cellular component | nuclear speck |
GO_0035145 | Cellular component | exon-exon junction complex |
GO_0005654 | Cellular component | nucleoplasm |
GO_0030425 | Cellular component | dendrite |
GO_0005829 | Cellular component | cytosol |
GO_0071006 | Cellular component | U2-type catalytic step 1 spliceosome |
GO_0031965 | Cellular component | nuclear membrane |
GO_0010494 | Cellular component | cytoplasmic stress granule |
GO_0005634 | Cellular component | nucleus |
GO_0019899 | Molecular function | enzyme binding |
GO_0031625 | Molecular function | ubiquitin protein ligase binding |
GO_0042802 | Molecular function | identical protein binding |
GO_0003729 | Molecular function | mRNA binding |
GO_0003723 | Molecular function | RNA binding |
GO_0005515 | Molecular function | protein binding |
Gene name | CASC3 |
Protein name | Protein CASC3 Protein CASC3 (Cancer susceptibility candidate gene 3 protein) (Metastatic lymph node gene 51 protein) (MLN 51) (Protein barentsz) (Btz) CASC3 exon junction complex subunit |
Synonyms | MLN51 |
Description | FUNCTION: Required for pre-mRNA splicing as component of the spliceosome . Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homomer. . |
Accessions | K7EQ38 ENST00000584997.1 ENST00000264645.12 ENST00000474190.1 J3QSC4 J3KSY7 ENST00000577605.1 O15234 |