CASC3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000184Biological processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO_0006417Biological processregulation of translation
GO_0000398Biological processmRNA splicing, via spliceosome
GO_0006406Biological processmRNA export from nucleus
GO_2000622Biological processregulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO_0008298Biological processintracellular mRNA localization
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016607Cellular componentnuclear speck
GO_0035145Cellular componentexon-exon junction complex
GO_0005654Cellular componentnucleoplasm
GO_0030425Cellular componentdendrite
GO_0005829Cellular componentcytosol
GO_0071006Cellular componentU2-type catalytic step 1 spliceosome
GO_0031965Cellular componentnuclear membrane
GO_0010494Cellular componentcytoplasmic stress granule
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0042802Molecular functionidentical protein binding
GO_0003729Molecular functionmRNA binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCASC3
Protein nameProtein CASC3
Protein CASC3 (Cancer susceptibility candidate gene 3 protein) (Metastatic lymph node gene 51 protein) (MLN 51) (Protein barentsz) (Btz)
CASC3 exon junction complex subunit
SynonymsMLN51
DescriptionFUNCTION: Required for pre-mRNA splicing as component of the spliceosome . Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homomer. .

AccessionsK7EQ38
ENST00000584997.1
ENST00000264645.12
ENST00000474190.1
J3QSC4
J3KSY7
ENST00000577605.1
O15234