CARM1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032259Biological processmethylation
GO_0033146Biological processregulation of intracellular estrogen receptor signaling pathway
GO_0006338Biological processchromatin remodeling
GO_1904037Biological processpositive regulation of epithelial cell apoptotic process
GO_0071932Biological processreplication fork reversal
GO_0051591Biological processresponse to cAMP
GO_0019919Biological processpeptidyl-arginine methylation, to asymmetrical-dimethyl arginine
GO_0045943Biological processpositive regulation of transcription by RNA polymerase I
GO_0045600Biological processpositive regulation of fat cell differentiation
GO_0006355Biological processregulation of DNA-templated transcription
GO_0008284Biological processpositive regulation of cell population proliferation
GO_2000171Biological processnegative regulation of dendrite development
GO_0043596Cellular componentnuclear replication fork
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0070611Molecular functionhistone H3R2 methyltransferase activity
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0070577Molecular functionlysine-acetylated histone binding
GO_0035642Molecular functionhistone H3R17 methyltransferase activity
GO_0008013Molecular functionbeta-catenin binding
GO_0042054Molecular functionhistone methyltransferase activity
GO_0008469Molecular functionhistone arginine N-methyltransferase activity
GO_0008276Molecular functionprotein methyltransferase activity
GO_0016274Molecular functionprotein-arginine N-methyltransferase activity
GO_0035242Molecular functionprotein-arginine omega-N asymmetric methyltransferase activity
GO_0003713Molecular functiontranscription coactivator activity
GO_0030374Molecular functionnuclear receptor coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCARM1
Protein nameCoactivator associated arginine methyltransferase 1
type I protein arginine methyltransferase (EC 2.1.1.319)
Histone-arginine methyltransferase CARM1 (EC 2.1.1.319) (Coactivator-associated arginine methyltransferase 1) (Protein arginine N-methyltransferase 4)
SynonymsPRMT4
DescriptionFUNCTION: Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability . Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activates transcription via chromatin remodeling . During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription (By similarity). During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C (By similarity). During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B (By similarity). Acts as a coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue (By similarity). Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors (By similarity). Also seems to be involved in p53/TP53 transcriptional activation (By similarity). Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation . Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs (By similarity). Acts as a transcriptional coactivator of ACACA/acetyl-CoA carboxylase by enriching H3R17 methylation at its promoter, thereby positively regulating fatty acid synthesis (By similarity). Independently of its methyltransferase activity, involved in replication fork progression: promotes PARP1 recruitment to replication forks, leading to poly-ADP-ribosylation of chromatin at replication forks and reduced fork speed . .

AccessionsENST00000586298.1
K7EK20
ENST00000588947.5
Q86X55
K7EIQ8
K7EQA8
ENST00000710361.1
ENST00000344150.8 [Q86X55-1]
ENST00000327064.9 [Q86X55-3]
ENST00000590039.5
ENST00000590699.5
K7ERM3
ENST00000589693.1
ENST00000586221.5
K7EQB9
A0AA34QVH5
K7EPK1