I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 10 studies | 69% ± 21% | |
| GABAergic neuron | 7 studies | 42% ± 19% | |
| neuron | 4 studies | 36% ± 19% | |
| interneuron | 3 studies | 51% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 10 studies | 69% ± 21% | |
| GABAergic neuron | 7 studies | 42% ± 19% | |
| neuron | 4 studies | 36% ± 19% | |
| interneuron | 3 studies | 51% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 12 studies | 37% ± 25% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 87% | 42310.94 | 2302 / 2642 | 96% | 83.34 | 675 / 705 |
| muscle | 100% | 7313.28 | 800 / 803 | 0% | 0 | 0 / 0 |
| uterus | 31% | 494.32 | 52 / 170 | 20% | 1.71 | 92 / 459 |
| eye | 0% | 0 | 0 / 0 | 34% | 0.81 | 27 / 80 |
| adrenal gland | 0% | 4.95 | 1 / 258 | 33% | 1.93 | 76 / 230 |
| skin | 0% | 9.16 | 6 / 1809 | 30% | 0.86 | 142 / 472 |
| heart | 23% | 363.91 | 201 / 861 | 0% | 0 | 0 / 0 |
| bladder | 14% | 185.29 | 3 / 21 | 5% | 0.18 | 27 / 504 |
| esophagus | 5% | 75.65 | 76 / 1445 | 11% | 0.23 | 21 / 183 |
| tonsil | 0% | 0 | 0 / 0 | 13% | 0.40 | 6 / 45 |
| pancreas | 0% | 0 | 0 / 328 | 12% | 0.16 | 21 / 178 |
| liver | 0% | 0 | 0 / 226 | 7% | 0.34 | 29 / 406 |
| lung | 0% | 5.42 | 2 / 578 | 6% | 0.13 | 70 / 1155 |
| prostate | 1% | 14.87 | 2 / 245 | 5% | 0.18 | 25 / 502 |
| stomach | 1% | 7.31 | 2 / 359 | 5% | 0.12 | 14 / 286 |
| breast | 0% | 4.60 | 1 / 459 | 3% | 0.07 | 34 / 1118 |
| intestine | 0% | 6.64 | 4 / 966 | 3% | 0.05 | 14 / 527 |
| kidney | 0% | 0 | 0 / 89 | 1% | 0.05 | 13 / 901 |
| ovary | 0% | 0 | 0 / 180 | 1% | 0.02 | 5 / 430 |
| thymus | 0% | 4.21 | 1 / 653 | 1% | 0.03 | 5 / 605 |
| adipose | 0% | 3.44 | 3 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 0% | 1.69 | 1 / 1335 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0018105 | Biological process | peptidyl-serine phosphorylation |
| GO_1990443 | Biological process | peptidyl-threonine autophosphorylation |
| GO_0002931 | Biological process | response to ischemia |
| GO_2001222 | Biological process | regulation of neuron migration |
| GO_0010666 | Biological process | positive regulation of cardiac muscle cell apoptotic process |
| GO_0046928 | Biological process | regulation of neurotransmitter secretion |
| GO_0035458 | Biological process | cellular response to interferon-beta |
| GO_0051092 | Biological process | positive regulation of NF-kappaB transcription factor activity |
| GO_0048168 | Biological process | regulation of neuronal synaptic plasticity |
| GO_0060996 | Biological process | dendritic spine development |
| GO_0038166 | Biological process | angiotensin-activated signaling pathway |
| GO_0051346 | Biological process | negative regulation of hydrolase activity |
| GO_1902108 | Biological process | regulation of mitochondrial membrane permeability involved in apoptotic process |
| GO_0051928 | Biological process | positive regulation of calcium ion transport |
| GO_2000124 | Biological process | regulation of endocannabinoid signaling pathway |
| GO_0006468 | Biological process | protein phosphorylation |
| GO_0046777 | Biological process | protein autophosphorylation |
| GO_0006816 | Biological process | calcium ion transport |
| GO_0046427 | Biological process | positive regulation of receptor signaling pathway via JAK-STAT |
| GO_0000082 | Biological process | G1/S transition of mitotic cell cycle |
| GO_0071346 | Biological process | cellular response to type II interferon |
| GO_0043197 | Cellular component | dendritic spine |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0030666 | Cellular component | endocytic vesicle membrane |
| GO_0005954 | Cellular component | calcium- and calmodulin-dependent protein kinase complex |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0043005 | Cellular component | neuron projection |
| GO_0005829 | Cellular component | cytosol |
| GO_0014069 | Cellular component | postsynaptic density |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0106310 | Molecular function | protein serine kinase activity |
| GO_0004674 | Molecular function | protein serine/threonine kinase activity |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0005524 | Molecular function | ATP binding |
| GO_0016301 | Molecular function | kinase activity |
| GO_0035254 | Molecular function | glutamate receptor binding |
| GO_0004683 | Molecular function | calmodulin-dependent protein kinase activity |
| GO_0005516 | Molecular function | calmodulin binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | CAMK2A |
| Protein name | Calcium/calmodulin dependent protein kinase II alpha Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17) Ca2+/calmodulin-dependent protein kinase II alpha subunit calcium/calmodulin-dependent protein kinase (EC 2.7.11.17) Alternative protein CAMK2A |
| Synonyms | CAMKA KIAA0968 hCG_38614 |
| Description | FUNCTION: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation . Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development . Also regulates the migration of developing neurons . Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity . Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA (By similarity). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway . In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway . Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity). . |
| Accessions | A0A5F9ZH50 ENST00000682786.1 [Q9UQM7-2] A0A5K1VW76 ENST00000672829.1 A0A804HIC9 A0A8V8TME7 ENST00000672785.1 ENST00000348628.11 [Q9UQM7-1] Q7LDD5 L8ECG5 ENST00000510347.2 ENST00000672089.1 A8K161 ENST00000398376.8 ENST00000671881.1 [Q9UQM7-2] ENST00000683506.1 A0A5F9ZH21 A0A5F9ZHR5 Q9UQM7 A0A5F9ZHY2 Q8IWE0 A0A5F9ZHM9 A0A804HLD1 Q27I69 ENST00000683332.1 ENST00000351010.6 D6RFJ0 ENST00000672752.1 ENST00000672396.1 ENST00000672479.1 [Q9UQM7-1] |
