CALD1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051017Biological processactin filament bundle assembly
GO_0001525Biological processangiogenesis
GO_0006936Biological processmuscle contraction
GO_0001725Cellular componentstress fiber
GO_0015629Cellular componentactin cytoskeleton
GO_0030016Cellular componentmyofibril
GO_0005856Cellular componentcytoskeleton
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0030478Cellular componentactin cap
GO_0045296Molecular functioncadherin binding
GO_0017022Molecular functionmyosin binding
GO_0005523Molecular functiontropomyosin binding
GO_0005516Molecular functioncalmodulin binding
GO_0005515Molecular functionprotein binding
GO_0003779Molecular functionactin binding

IV. Literature review

[source]
Gene nameCALD1
Protein nameCaldesmon 1
Caldesmon (CDM)
Caldesmon 1, isoform CRA_b (NAG22 protein)
CALD1 protein
Caldesmon 1, isoform CRA_i (Testis secretory sperm-binding protein Li 227n)
SynonymsCDM
hCG_17453
CAD
DescriptionFUNCTION: Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity). .

AccessionsENST00000430085.5
ENST00000445569.6
ENST00000424922.5 [Q05682-5]
ENST00000495522.1
C9J813
ENST00000436461.6
A0A6Q8PGI1
ENST00000361675.7 [Q05682-1]
Q9NYG1
Q05DR4
ENST00000417172.5 [Q05682-4]
ENST00000361901.6 [Q05682-4]
ENST00000454108.5
ENST00000422748.5 [Q05682-6]
E7EX44
E9PGZ1
Q6P707
C9JE79
Q05682
F8WE61
C9JEK3
ENST00000393118.7 [Q05682-3]
ENST00000466704.1
ENST00000443197.5
ENST00000435928.1
A0A140VKA0
Q6PJM5