CACNB4 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
glutamatergic neuron	13 studies	60% ± 26%	Explore
GABAergic neuron	9 studies	56% ± 27%	Explore
oligodendrocyte precursor cell	9 studies	41% ± 15%	Explore
microglial cell	8 studies	43% ± 13%	Explore
amacrine cell	7 studies	46% ± 20%	Explore
astrocyte	7 studies	33% ± 16%	Explore
interneuron	6 studies	63% ± 18%	Explore
neuron	5 studies	36% ± 12%	Explore
type II pneumocyte	5 studies	37% ± 8%	Explore
endothelial cell	4 studies	41% ± 22%	Explore
epithelial cell	4 studies	29% ± 14%	Explore
retinal ganglion cell	4 studies	24% ± 11%	Explore
GABAergic interneuron	3 studies	62% ± 9%	Explore
retina horizontal cell	3 studies	19% ± 3%	Explore
GABAergic amacrine cell	3 studies	41% ± 14%	Explore
glycinergic amacrine cell	3 studies	36% ± 1%	Explore
retinal pigment epithelial cell	3 studies	24% ± 3%	Explore
ependymal cell	3 studies	28% ± 14%	Explore
basal cell	3 studies	30% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	14 studies	44% ± 22%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	99%	3925.29	2617 / 2642	81%	2.11	569 / 705
prostate	93%	657.78	227 / 245	7%	0.12	37 / 502
bladder	90%	819.14	19 / 21	3%	0.08	16 / 504
esophagus	76%	345.91	1094 / 1445	5%	0.10	10 / 183
blood vessel	77%	380.12	1029 / 1335	0%	0	0 / 0
kidney	69%	283.92	61 / 89	4%	0.11	38 / 901
thymus	60%	199.16	392 / 653	11%	0.22	67 / 605
breast	64%	273.53	293 / 459	7%	0.14	79 / 1118
lung	62%	288.15	357 / 578	6%	0.12	65 / 1155
skin	63%	447.30	1146 / 1809	1%	0.01	3 / 472
adipose	50%	243.57	600 / 1204	0%	0	0 / 0
adrenal gland	44%	130.76	114 / 258	3%	0.04	6 / 230
stomach	36%	111.15	128 / 359	1%	0.02	3 / 286
uterus	25%	70.56	43 / 170	2%	0.02	7 / 459
intestine	21%	58.34	202 / 966	1%	0.01	5 / 527
spleen	20%	52.63	47 / 241	0%	0	0 / 0
peripheral blood	19%	389.99	179 / 929	0%	0	0 / 0
ovary	9%	24.71	17 / 180	0%	0.00	1 / 430
lymph node	0%	0	0 / 0	7%	0.11	2 / 29
heart	4%	11.31	33 / 861	0%	0	0 / 0
pancreas	3%	6.72	9 / 328	0%	0	0 / 178
liver	0%	0	0 / 226	2%	0.03	7 / 406
muscle	1%	1.66	5 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0007628	Biological process	adult walking behavior
GO_0008285	Biological process	negative regulation of cell population proliferation
GO_0055001	Biological process	muscle cell development
GO_1904751	Biological process	positive regulation of protein localization to nucleolus
GO_1990830	Biological process	cellular response to leukemia inhibitory factor
GO_0050852	Biological process	T cell receptor signaling pathway
GO_0048541	Biological process	Peyer's patch development
GO_1901385	Biological process	regulation of voltage-gated calcium channel activity
GO_0007528	Biological process	neuromuscular junction development
GO_0048536	Biological process	spleen development
GO_0046058	Biological process	cAMP metabolic process
GO_0050908	Biological process	detection of light stimulus involved in visual perception
GO_0007268	Biological process	chemical synaptic transmission
GO_0048538	Biological process	thymus development
GO_0099509	Biological process	regulation of presynaptic cytosolic calcium ion concentration
GO_2000134	Biological process	negative regulation of G1/S transition of mitotic cell cycle
GO_0007214	Biological process	gamma-aminobutyric acid signaling pathway
GO_2000300	Biological process	regulation of synaptic vesicle exocytosis
GO_0070588	Biological process	calcium ion transmembrane transport
GO_0014051	Biological process	gamma-aminobutyric acid secretion
GO_0035249	Biological process	synaptic transmission, glutamatergic
GO_0019227	Biological process	neuronal action potential propagation
GO_0098978	Cellular component	glutamatergic synapse
GO_0098793	Cellular component	presynapse
GO_0009898	Cellular component	cytoplasmic side of plasma membrane
GO_0016607	Cellular component	nuclear speck
GO_0005891	Cellular component	voltage-gated calcium channel complex
GO_0005829	Cellular component	cytosol
GO_0019901	Molecular function	protein kinase binding
GO_0099626	Molecular function	voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels
GO_0005245	Molecular function	voltage-gated calcium channel activity
GO_0008331	Molecular function	high voltage-gated calcium channel activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	CACNB4
Protein name	Calcium voltage-gated channel auxiliary subunit beta 4 Voltage dependent calcium channel beta 4 subunit Voltage-dependent L-type calcium channel subunit beta-3 (Calcium channel voltage-dependent subunit beta 3) Uncharacterized protein CACNB4 Voltage-dependent L-type calcium channel subunit beta-4 (CAB4) (Calcium channel voltage-dependent subunit beta 4)
Synonyms	CACNLB4
Description	FUNCTION: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. .
Accessions	A0A1B0GTN2 A0A1B0GTP6 A0A1B0GTA9 A0A1B0GTL1 A0A1B0GUW8 A0A1B0GUJ7 ENST00000636785.1 A0A1B0GTK1 ENST00000637330.1 ENST00000636496.1 A0A1B0GVP7 A0A1B0GUK4 ENST00000637436.1 A0A1B0GVF0 ENST00000636350.1 ENST00000434468.2 A0A1B0GUM9 ENST00000636773.1 A0A1B0GW58 A0A1B0GTS4 ENST00000636390.1 ENST00000637217.1 ENST00000201943.10 [O00305-4] A0A1B0GU32 ENST00000636130.1 ENST00000534999.7 [O00305-2] A0A1B0GW81 A0A1B0GTN8 ENST00000637514.1 ENST00000636947.1 A0A1B0GU42 ENST00000637535.1 A0A1B0GTP5 A0A1B0GU05 E7DBM8 A0A1B0GTH0 E7EN11 ENST00000637232.1 ENST00000638056.1 ENST00000635738.1 A0A1B0GVT6 A0A1B0GUI5 ENST00000637007.1 Q53S65 A0A1B0GUU5 A0A1B0GVU5 ENST00000638150.1 A0A1B0GW63 ENST00000439467.6 Q9NZA2 A0A1B0GTX8 ENST00000637216.1 A0A1B0GWG5 ENST00000638005.1 [O00305-3] ENST00000637132.1 A0A1B0GUK3 ENST00000636129.1 ENST00000636598.1 ENST00000636901.1 A0A1B0GTX2 ENST00000397327.7 ENST00000637762.1 A0A1B0GU53 A0A1B0GUU8 ENST00000637284.1 ENST00000636507.1 ENST00000637309.1 ENST00000637224.1 ENST00000637491.1 H0Y476 ENST00000635890.1 A0A1B0GV16 ENST00000360283.11 ENST00000635904.1 ENST00000427385.6 ENST00000637547.1 ENST00000637559.1 A0A1B0GVB2 ENST00000637956.1 O00305 ENST00000637418.1 ENST00000638091.1 A0A1B0GWF9 A0A1B0GUI8 ENST00000636664.1 A0A1B0GTX6 ENST00000636380.1 ENST00000539935.7 [O00305-1] ENST00000636762.1 ENST00000636617.1 A0A1B0GVG1 ENST00000638040.1 Q580I4 ENST00000635930.1 ENST00000637779.1 ENST00000636442.1 ENST00000636721.1 ENST00000636108.1 ENST00000637828.1 A0A1B0GXG0 A0A1B0GTF6 A0A1B0GU07 ENST00000637550.1 A0A1C7CYX2 ENST00000637312.1 C9J224

CACNB4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review