CACNA1C report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0086012Biological processmembrane depolarization during cardiac muscle cell action potential
GO_0045762Biological processpositive regulation of adenylate cyclase activity
GO_0086002Biological processcardiac muscle cell action potential involved in contraction
GO_0045933Biological processpositive regulation of muscle contraction
GO_0098912Biological processmembrane depolarization during atrial cardiac muscle cell action potential
GO_0007507Biological processheart development
GO_0086064Biological processcell communication by electrical coupling involved in cardiac conduction
GO_0098703Biological processcalcium ion import across plasma membrane
GO_0061577Biological processcalcium ion transmembrane transport via high voltage-gated calcium channel
GO_0035115Biological processembryonic forelimb morphogenesis
GO_0010881Biological processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO_0002520Biological processimmune system development
GO_0007204Biological processpositive regulation of cytosolic calcium ion concentration
GO_0086045Biological processmembrane depolarization during AV node cell action potential
GO_0061337Biological processcardiac conduction
GO_0086091Biological processregulation of heart rate by cardiac conduction
GO_0060402Biological processcalcium ion transport into cytosol
GO_0043010Biological processcamera-type eye development
GO_0098911Biological processregulation of ventricular cardiac muscle cell action potential
GO_0070588Biological processcalcium ion transmembrane transport
GO_0098839Cellular componentpostsynaptic density membrane
GO_0005886Cellular componentplasma membrane
GO_1990454Cellular componentL-type voltage-gated calcium channel complex
GO_0016020Cellular componentmembrane
GO_0030018Cellular componentZ disc
GO_0043204Cellular componentperikaryon
GO_0030425Cellular componentdendrite
GO_0005891Cellular componentvoltage-gated calcium channel complex
GO_0014069Cellular componentpostsynaptic density
GO_0005737Cellular componentcytoplasm
GO_0086056Molecular functionvoltage-gated calcium channel activity involved in AV node cell action potential
GO_0086007Molecular functionvoltage-gated calcium channel activity involved in cardiac muscle cell action potential
GO_0051393Molecular functionalpha-actinin binding
GO_0005245Molecular functionvoltage-gated calcium channel activity
GO_0046872Molecular functionmetal ion binding
GO_0008331Molecular functionhigh voltage-gated calcium channel activity
GO_0005516Molecular functioncalmodulin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCACNA1C
Protein nameCalcium voltage-gated channel subunit alpha1 C (Voltage-gated L-type calcium channel Cav1.2 alpha 1 subunit, splice variant 10*)
Voltage-dependent L-type calcium channel subunit alpha
Calcium channel, voltage-dependent, L type, alpha 1C subunit
Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Voltage-gated calcium channel subunit alpha Cav1.2)
Voltage-gated L-type calcium channel Cav1.2 alpha 1 subunit, splice variant 9*
Calcium voltage-gated channel subunit alpha1 C
Voltage-dependent L-type calcium channel alpha 1C subunit
SynonymsCCHL1A1
CACNL1A1
CACH2
CACN2
DescriptionFUNCTION: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents . Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm . Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells . Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable). .; FUNCTION: (Microbial infection) Acts as a receptor for Influenzavirus . May play a critical role in allowing virus entry when sialylated and expressed on lung tissues . .

FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. .

FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. .

FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. .

FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. .

FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. .

FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. .

FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. .

FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. .

FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. .

FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. .

FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. .

FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. .

FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. .

FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. .

FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. .

AccessionsENST00000682462.1
A0A804HKC4
ENST00000644891.1 [Q13936-32]
Q86XX1
A0A804HIZ0
ENST00000399591.5 [Q13936-29]
ENST00000647327.2 [Q13936-37]
ENST00000402845.7 [Q13936-13]
ENST00000399595.5 [Q13936-25]
Q13936
ENST00000465278.3
ENST00000683840.1
A0A087WUX4
ENST00000643858.1 [Q13936-14]
A0A804HJB6
ENST00000643038.2 [Q13936-11]
ENST00000682835.1
ENST00000683482.1 [Q13936-35]
A0A0A0MR67
ENST00000344100.7 [Q13936-14]
ENST00000672806.1
ENST00000647521.1 [Q13936-25]
Q5V9X9
ENST00000327702.12
ENST00000645965.1 [Q13936-27]
ENST00000682686.1 [Q13936-19]
ENST00000399644.5 [Q13936-21]
ENST00000710479.1 [Q13936-35]
ENST00000399606.5 [Q13936-30]
ENST00000406454.8
ENST00000480911.6
A0A804HJR1
ENST00000399617.6
A0A804HKE9
ENST00000683824.1
ENST00000399649.5 [Q13936-15]
A0A804HHT8
F5GY28
ENST00000399601.5 [Q13936-20]
ENST00000399603.6 [Q13936-37]
ENST00000646257.1 [Q13936-21]
Q4G0H8
A0A804HIR0
ENST00000399638.5 [Q13936-31]
Q5V9X8
ENST00000399655.6 [Q13936-12]
ENST00000683956.1
ENST00000642583.1 [Q13936-29]
ENST00000647062.1 [Q13936-13]
ENST00000682336.1
ENST00000399629.5 [Q13936-32]
ENST00000644660.1 [Q13936-20]
ENST00000710487.1 [Q13936-19]
ENST00000644048.1 [Q13936-31]
A0A804HIJ8
ENST00000399634.6
ENST00000399641.6 [Q13936-23]
ENST00000643701.1 [Q13936-15]
ENST00000399597.5 [Q13936-22]
ENST00000644235.2 [Q13936-12]
ENST00000335762.10
ENST00000682343.2
A0A0A0MSA1
A0A804HI37
ENST00000399637.5 [Q13936-27]
ENST00000682152.1
ENST00000683781.1
ENST00000682544.1
ENST00000645584.1 [Q13936-24]
F5H638
ENST00000644369.2 [Q13936-23]
A0AA34QVT1
ENST00000491104.2
ENST00000399621.5 [Q13936-24]
ENST00000644691.1 [Q13936-30]
ENST00000643138.1 [Q13936-22]
F5H522
ENST00000347598.9 [Q13936-11]
Q86XX0
A0A5F9ZHD9
E9PDI6