Name | Number of supported studies | Average coverage | |
---|---|---|---|
pericyte | 14 studies | 60% ± 23% | |
fibroblast | 13 studies | 42% ± 22% | |
endothelial cell | 13 studies | 44% ± 18% | |
smooth muscle cell | 12 studies | 61% ± 24% | |
glutamatergic neuron | 11 studies | 70% ± 22% | |
oligodendrocyte precursor cell | 10 studies | 34% ± 18% | |
GABAergic neuron | 9 studies | 62% ± 25% | |
astrocyte | 9 studies | 41% ± 22% | |
retina horizontal cell | 6 studies | 69% ± 27% | |
cardiac muscle cell | 6 studies | 86% ± 14% | |
neuron | 5 studies | 45% ± 15% | |
interneuron | 5 studies | 70% ± 27% | |
granule cell | 4 studies | 59% ± 22% | |
mesothelial cell | 4 studies | 51% ± 35% | |
retinal ganglion cell | 4 studies | 34% ± 17% | |
Purkinje cell | 3 studies | 58% ± 28% | |
microglial cell | 3 studies | 42% ± 24% | |
GABAergic amacrine cell | 3 studies | 51% ± 12% | |
Mueller cell | 3 studies | 28% ± 14% | |
amacrine cell | 3 studies | 51% ± 16% | |
glycinergic amacrine cell | 3 studies | 64% ± 8% | |
adipocyte | 3 studies | 32% ± 16% | |
retinal pigment epithelial cell | 3 studies | 65% ± 17% | |
myofibroblast cell | 3 studies | 59% ± 29% | |
oligodendrocyte | 3 studies | 36% ± 25% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 98% | 4721.82 | 240 / 245 | 89% | 3.20 | 446 / 502 |
brain | 77% | 2027.92 | 2046 / 2642 | 90% | 3.51 | 637 / 705 |
lung | 98% | 2859.04 | 568 / 578 | 54% | 1.66 | 624 / 1155 |
intestine | 83% | 11298.14 | 797 / 966 | 69% | 2.33 | 366 / 527 |
breast | 67% | 1126.94 | 306 / 459 | 79% | 2.44 | 878 / 1118 |
esophagus | 74% | 6170.61 | 1064 / 1445 | 66% | 1.97 | 120 / 183 |
uterus | 98% | 11189.12 | 167 / 170 | 34% | 2.28 | 154 / 459 |
bladder | 86% | 6711.52 | 18 / 21 | 45% | 1.33 | 225 / 504 |
stomach | 52% | 3040.20 | 186 / 359 | 71% | 2.92 | 204 / 286 |
blood vessel | 100% | 9112.47 | 1335 / 1335 | 0% | 0 | 0 / 0 |
heart | 97% | 7475.10 | 839 / 861 | 0% | 0 | 0 / 0 |
kidney | 43% | 774.46 | 38 / 89 | 54% | 2.03 | 486 / 901 |
pancreas | 2% | 26.92 | 6 / 328 | 93% | 4.43 | 165 / 178 |
spleen | 94% | 1999.67 | 226 / 241 | 0% | 0 | 0 / 0 |
adrenal gland | 10% | 134.41 | 26 / 258 | 75% | 4.37 | 172 / 230 |
adipose | 78% | 1639.86 | 938 / 1204 | 0% | 0 | 0 / 0 |
thymus | 24% | 356.23 | 157 / 653 | 48% | 1.30 | 293 / 605 |
skin | 42% | 976.52 | 762 / 1809 | 18% | 0.55 | 86 / 472 |
ovary | 35% | 803.97 | 63 / 180 | 23% | 0.58 | 97 / 430 |
tonsil | 0% | 0 | 0 / 0 | 18% | 0.27 | 8 / 45 |
liver | 0% | 4.86 | 1 / 226 | 12% | 0.25 | 49 / 406 |
lymph node | 0% | 0 | 0 / 0 | 7% | 0.07 | 2 / 29 |
eye | 0% | 0 | 0 / 0 | 4% | 0.05 | 3 / 80 |
muscle | 2% | 33.85 | 19 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0086012 | Biological process | membrane depolarization during cardiac muscle cell action potential |
GO_0045762 | Biological process | positive regulation of adenylate cyclase activity |
GO_0086002 | Biological process | cardiac muscle cell action potential involved in contraction |
GO_0045933 | Biological process | positive regulation of muscle contraction |
GO_0098912 | Biological process | membrane depolarization during atrial cardiac muscle cell action potential |
GO_0007507 | Biological process | heart development |
GO_0086064 | Biological process | cell communication by electrical coupling involved in cardiac conduction |
GO_0098703 | Biological process | calcium ion import across plasma membrane |
GO_0061577 | Biological process | calcium ion transmembrane transport via high voltage-gated calcium channel |
GO_0035115 | Biological process | embryonic forelimb morphogenesis |
GO_0010881 | Biological process | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion |
GO_0002520 | Biological process | immune system development |
GO_0007204 | Biological process | positive regulation of cytosolic calcium ion concentration |
GO_0086045 | Biological process | membrane depolarization during AV node cell action potential |
GO_0061337 | Biological process | cardiac conduction |
GO_0086091 | Biological process | regulation of heart rate by cardiac conduction |
GO_0060402 | Biological process | calcium ion transport into cytosol |
GO_0043010 | Biological process | camera-type eye development |
GO_0098911 | Biological process | regulation of ventricular cardiac muscle cell action potential |
GO_0070588 | Biological process | calcium ion transmembrane transport |
GO_0098839 | Cellular component | postsynaptic density membrane |
GO_0005886 | Cellular component | plasma membrane |
GO_1990454 | Cellular component | L-type voltage-gated calcium channel complex |
GO_0016020 | Cellular component | membrane |
GO_0030018 | Cellular component | Z disc |
GO_0043204 | Cellular component | perikaryon |
GO_0030425 | Cellular component | dendrite |
GO_0005891 | Cellular component | voltage-gated calcium channel complex |
GO_0014069 | Cellular component | postsynaptic density |
GO_0005737 | Cellular component | cytoplasm |
GO_0086056 | Molecular function | voltage-gated calcium channel activity involved in AV node cell action potential |
GO_0086007 | Molecular function | voltage-gated calcium channel activity involved in cardiac muscle cell action potential |
GO_0051393 | Molecular function | alpha-actinin binding |
GO_0005245 | Molecular function | voltage-gated calcium channel activity |
GO_0046872 | Molecular function | metal ion binding |
GO_0008331 | Molecular function | high voltage-gated calcium channel activity |
GO_0005516 | Molecular function | calmodulin binding |
GO_0005515 | Molecular function | protein binding |
Gene name | CACNA1C |
Protein name | Calcium voltage-gated channel subunit alpha1 C (Voltage-gated L-type calcium channel Cav1.2 alpha 1 subunit, splice variant 10*) Voltage-dependent L-type calcium channel subunit alpha Calcium channel, voltage-dependent, L type, alpha 1C subunit Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Voltage-gated calcium channel subunit alpha Cav1.2) Voltage-gated L-type calcium channel Cav1.2 alpha 1 subunit, splice variant 9* Calcium voltage-gated channel subunit alpha1 C Voltage-dependent L-type calcium channel alpha 1C subunit |
Synonyms | CCHL1A1 CACNL1A1 CACH2 CACN2 |
Description | FUNCTION: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents . Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm . Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells . Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable). .; FUNCTION: (Microbial infection) Acts as a receptor for Influenzavirus . May play a critical role in allowing virus entry when sialylated and expressed on lung tissues . . FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. . FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. . FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. . FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. . FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. . FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. . FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. . FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. . FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. . FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. . FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. . FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. . FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. . FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. . FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. . |
Accessions | ENST00000682462.1 A0A804HKC4 ENST00000644891.1 [Q13936-32] Q86XX1 A0A804HIZ0 ENST00000399591.5 [Q13936-29] ENST00000647327.2 [Q13936-37] ENST00000402845.7 [Q13936-13] ENST00000399595.5 [Q13936-25] Q13936 ENST00000465278.3 ENST00000683840.1 A0A087WUX4 ENST00000643858.1 [Q13936-14] A0A804HJB6 ENST00000643038.2 [Q13936-11] ENST00000682835.1 ENST00000683482.1 [Q13936-35] A0A0A0MR67 ENST00000344100.7 [Q13936-14] ENST00000672806.1 ENST00000647521.1 [Q13936-25] Q5V9X9 ENST00000327702.12 ENST00000645965.1 [Q13936-27] ENST00000682686.1 [Q13936-19] ENST00000399644.5 [Q13936-21] ENST00000710479.1 [Q13936-35] ENST00000399606.5 [Q13936-30] ENST00000406454.8 ENST00000480911.6 A0A804HJR1 ENST00000399617.6 A0A804HKE9 ENST00000683824.1 ENST00000399649.5 [Q13936-15] A0A804HHT8 F5GY28 ENST00000399601.5 [Q13936-20] ENST00000399603.6 [Q13936-37] ENST00000646257.1 [Q13936-21] Q4G0H8 A0A804HIR0 ENST00000399638.5 [Q13936-31] Q5V9X8 ENST00000399655.6 [Q13936-12] ENST00000683956.1 ENST00000642583.1 [Q13936-29] ENST00000647062.1 [Q13936-13] ENST00000682336.1 ENST00000399629.5 [Q13936-32] ENST00000644660.1 [Q13936-20] ENST00000710487.1 [Q13936-19] ENST00000644048.1 [Q13936-31] A0A804HIJ8 ENST00000399634.6 ENST00000399641.6 [Q13936-23] ENST00000643701.1 [Q13936-15] ENST00000399597.5 [Q13936-22] ENST00000644235.2 [Q13936-12] ENST00000335762.10 ENST00000682343.2 A0A0A0MSA1 A0A804HI37 ENST00000399637.5 [Q13936-27] ENST00000682152.1 ENST00000683781.1 ENST00000682544.1 ENST00000645584.1 [Q13936-24] F5H638 ENST00000644369.2 [Q13936-23] A0AA34QVT1 ENST00000491104.2 ENST00000399621.5 [Q13936-24] ENST00000644691.1 [Q13936-30] ENST00000643138.1 [Q13936-22] F5H522 ENST00000347598.9 [Q13936-11] Q86XX0 A0A5F9ZHD9 E9PDI6 |