CABLES1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051301Biological processcell division
GO_0007399Biological processnervous system development
GO_0051726Biological processregulation of cell cycle
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCABLES1
Protein nameCdk5 and Abl enzyme substrate 1
CDK5 and ABL1 enzyme substrate 1 (Interactor with CDK3 1) (Ik3-1)
SynonymsCABLES
DescriptionFUNCTION: Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity). .

AccessionsA0A0G2JLG8
ENST00000420687.2 [Q8TDN4-2]
ENST00000579963.5
ENST00000582882.5
ENST00000580153.5
ENST00000400473.6 [Q8TDN4-4]
J3QRY5
Q8TDN4
V9GYB4
ENST00000256925.12 [Q8TDN4-1]